Skip to main content
Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

Fig. 3

Mangafodipir rescues follicles from anticancer drug-induced apoptosis. a Representative images of immunohistochemistry for cleaved caspase-3 in ovaries treated with 7.5 (CIS7.5) or 20 (CIS20) mg/kg cisplatin, or 7.5 (PTX7.5) or 20 (PTX20) mg/kg paclitaxel, with or without mangafodipir (+/− Mangafodipir, respectively). Bar, 100 μm. b Cleaved caspase-3 (CC3) immunoreactive intensity scores. Mean ± SD, *, p < 0.05. c Mangafodipir (m.10 mg/kg) significantly reduced cleaved caspase-3 levels induced by 7.5 (CIS7.5) or 20 (CIS20) mg/kg cisplatin, 7.5 (PTX7.5) mg/kg paclitaxel, but not by 20 (PTX20) mg/kg paclitaxel. The relative intensities of cleaved caspase-3 (CC3) signals were normalized to those of β-actin to assess the results of immunoblot in mice ovaries. Mean ± SEM, *, p < 0.05 vs. each control (m0)

Back to article page