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Table 1 The Characteristics of Selected Studies

From: Meta-analysis of ART outcomes in women with different preconception TSH levels

Author

Year

N

Country

Study design

Assays

used

TSH

Cut-off

ART

details

Outcomes

Coelho

2016

650

Brazil

retrospective

a third-generation assay

2.5:4.0

IVF/ICSI

PR; CPR; LBR; MR

Aghahosseini

2013

816

Iran

retrospective

NS

2.5

IVF

CPR

Mintziori

2014

158

Greece

retrospective

ELISA

2.5

IVF

PR; CPR; LBR; MR

Unuane

2017

3143

Belgium

retrospective

NS

2.5

IUI

PR; LBR; MR

Michalakis

2011

1216

USA

retrospective

NS

2.5;4.0

NS

PR; CPR; LBR; MR

Muller

1999

141

Netherlands

prospective

an immunoluminometric assay

4.5

IVF

PR; LBR; MR

Chai

2014

505

China

retrospective

Access HYPERsensitive hTSH

Reagent Pack and Access Free

T4 Reagent Pack

2.5;4.5

IVF/

ICSI

CPR; LBR; MR

Baker

2006

146

USA

retrospective

chemiluminometric technology

2.5

IVF

LBR

Karmon

2014

1477

USA

prospective

third-generation assays

2.5

IUI

CPR; LBR

Weghofer

2015

98

USA

retrospective

Electrochemiluminescence

immunoassay

2.5

IVF

CPR; LBR

Seungdamrong

2017

1306

USA

prospective

Immulite 2000 system

2.5

IUI

PR; CPR; LBR; MR

Wu

2017

138

China

prospective

NS

2.5; 5

IVF/

ICSI

PR; CPR; LBR; MR

Ba

2013

413

China

prospective

NS

4.2

IVF/

ICSI

PR; CPR; LBR; MR

Zhang

2012

1832

China

retrospective

NS

3.9

IVF/

ICSI

PR; CPR; LBR; MR

Zeng

2014

375

China

prospective

Chemiluminescent

immunoassay

2.5;3.5

IVF/

ICSI

CPR; LBR; MR

Gingold

2016

1201

USA

retrospective

NS

2.5;5.0

IVF

PR; CPR; LBR

Reh

2010

1055

USA

retrospective

NS

2.5;4.5

IVF

CPR; LBR; MR

Cai

2017

176

China

prospective

electro- chemiluminescence immunoassays

2.5

IVF

CPR; LBR; MR

  1. IVF In vitro fertilization, ICSI intracytoplasmatic sperm injection, IUI intra-uterine insemination, ART assisted reproduction technology, TSH thyroid stimulating hormone, CPR clinical pregnancy rate, MR miscarriage rate, LBR live birth rate, PR pregnancy rate, ELISA enzyme-linked immunosorbent assay