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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Shifting perspectives from “oncogenic” to oncofetal proteins; how these factors drive placental development

Fig. 3

Angiogenesis in the placenta. During the first trimester FGF promotes vasculogenesis by promoting the differentiation of mesenchymal stem cells into hemangiogenic progenitor cells. These cells aggregate to form hemangiogenic cords and eventually primitive capillaries. VEGF-A promotes the angiogenesis of these capillaries through branching angiogenesis. As pregnancy progresses, PlGF is upregulated leading to non-branching angiogenesis and elongated capillaries

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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