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Table 2 Summary of results of treatment options with regard to implantation rate, clinical pregnancy rate, and live birth rate

From: Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions

  Implantation Rate Clinical Pregnancy Rate Live Birth Outcome Source
(treatment vs. control) (treatment vs. control) (treatment vs. control)
Tacrolimus 45.7% vs. 0% 64% vs. 0% 60% vs. 0% Nakagawa et al., 2015 [36]
(P < 0.0001) (P < 0.0001) (P < 0.0001)
IVIG 34.4% vs. 13.7% 60.2% vs. 39.3% 49.8% vs. 31.6% Li et al., 2013 [82] (meta-analysis)
RR 2.708 RR 1.475 RR 1.616
(95% CI: 1.302–5.629, I2 = 65.0%) (95% CI: 1.191–1.825, I2 = 65.7%) (95% CI: 1.243–2.101, I2 = 58.2%)
PBMC 22% vs. 4.88% 39.58% vs. 14.29% 33.33% vs.9.58% Li et al., 2017 [84]
(P = 0.014) (P = 0.038) (P = 0.038)
G-CSF 31.5% vs. 13.9% 48.1% vs. 25% 33.3% vs. 17.3% Xu et al., 2015 [87]
(P < 0.01) (P < 0.01) NS
Antibiotics for CE 37% vs. 17% 65.2% vs. 33% 60.8% vs. 13.3% Cicinelli et al., 2015 [44]
NS (P = 0.039) (P = 0.02)
Salpingectomy 25.6% vs. 12.3% 45.7% vs. 22.5% 40% vs. 17.5% Strandell et al., 1999 [94]
(P = 0.038) (P = 0.029) (P = 0.038)
Endometrial Biopsy 27.7%, vs. 14.2% 66.7% vs. 30.3% 48.9% vs. 22.5% Barash et al., 2003 [96]
(P = .00011) (P = .00009) (P = .016)
IMSI procedure 19.2% vs. 7.8% 43.1% vs. 10.5% 34.7% vs. 0% Shalom-Paz et al., 2015 [109]
(P = 0.042) (P = 0.02) (P = 0.003)