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Table 2 Cycle characteristics and pregnancy outcome of poor ovarian responders with or without DHEA

From: Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study

Parameters POR (n = 84) POR with DHEA (n = 67) p value
Stimulation duration (days) 10.1 ± 2.2 10.5 ± 1.9 0.310
Gonadotropin dosage (IU) 2884.4 ± 872.5 2975.4 ± 649.4 0.126
No. of oocytes retrieved (n) 2.0 ± 1.5 3.3 ± 2.5 < 0.001
Oocytes retrieved > 3, % (n) 14.3 (12/84) 34.3 (23/67) 0.004
No. of metaphase II oocytes (n) 1.0 ± 1.1 1.9 ± 1.5 < 0.001
Maturation rate (%) 35.5 ± 36.2 56.2 ± 33.9 < 0.001
No. of fertilized oocytes (n) 1.4 ± 1.2 2.3 ± 1.7 < 0.001
Fertilization rate (%) 58.0 ± 42.5 67.9 ± 32.7 0.108
No. of Day 3 embryos (n) 1.3 ± 1.2 2.1 ± 1.6 0.001
No. of top-quality Day 3 embryos (n) 0.4 ± 0.8 1.0 ± 1.1 0.001
Clinical pregnancy rate, % (n) 7.1 (6/84) 23.9 (16/67) 0.004
Ongoing pregnancy rate, % (n) 6.0 (5/84) 17.9 (12/67) 0.021
Live birth rate, % (n) 6.0 (5/84) 16.4 (11/67) 0.038
Cancellation rate, % (n) 16.7 (14/84) 10.4 (7/67) 0.273
  1. Data are presented as mean ± standard deviation and % (n)
  2. POR poor ovarian responder, DHEA dehydroepiandrosterone