Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study

Table 3 Ovarian follicles behavior under letrozole plus HMG or HMG-only stimulation protocol

Parameter	GROUP 1 (LET-HMG)	GROUP 2 (HMG)	p-value*
Day 5 follicles< 10 mm	9 (5.5–11) [0–21]	9 (8–13) [4–20]	0.097
Day 8 follicles < 10 mm	4 (2–7) [0–13]	5 (4–8) [2–18]	0.031^p
hCG day follicles< 10 mm	3 (0–4) [0–11]	4 (2–4.7) [0–13]	0.024^p
Day 5 follicles > 11 mm	3 (1–5.5) [0–20]	2 (1–4) [0–8]	0.131
Day 8 follicles > 13 mm	6 (5–8) [0–23]	5 (2–7) [1–20]	0.009^p
hCG day follicles > 16 mm	7 (6–9) [3–25]	7 (6–9) [3–15]	0.836

Data are displayed as median with upper and lower range in round parentheses and ranges in squared parentheses
*Two-tailed Mann-Whitney test
^pthe study is powered to detect this difference

ISSN: 1477-7827