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Table 3 Ovarian follicles behavior under letrozole plus HMG or HMG-only stimulation protocol

From: Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study

Parameter GROUP 1 (LET-HMG) GROUP 2 (HMG) p-value*
Day 5 follicles< 10 mm 9 (5.5–11) [0–21] 9 (8–13) [4–20] 0.097
Day 8 follicles < 10 mm 4 (2–7) [0–13] 5 (4–8) [2–18] 0.031p
hCG day follicles< 10 mm 3 (0–4) [0–11] 4 (2–4.7) [0–13] 0.024p
Day 5 follicles > 11 mm 3 (1–5.5) [0–20] 2 (1–4) [0–8] 0.131
Day 8 follicles > 13 mm 6 (5–8) [0–23] 5 (2–7) [1–20] 0.009p
hCG day follicles > 16 mm 7 (6–9) [3–25] 7 (6–9) [3–15] 0.836
  1. Data are displayed as median with upper and lower range in round parentheses and ranges in squared parentheses
  2. *Two-tailed Mann-Whitney test
  3. pthe study is powered to detect this difference