Table 2 Stimulation and IVF outcome variables of PCOS patients under letrozole plus HMG or HMG-only stimulation protocol
Group 1 (Let-HMG) | Group 2 (HMG) | p-value | |
|---|---|---|---|
Days of stimulation (N) | 11 (10–12) [8–15] | 10 (10–12) [9–15] | 0.246* |
HMG dose (units) | 1350 (1200–1500) [626–2475] | 1800 (1337–3110) [1050–5325] | < 0.0001*p |
E2 day 5 (pg/ml) | 103 (73–182) [14–495] | 525 (284–703) [82–1328] | < 0.0001*p |
E2 day 8 (pg/ml) | 502 (322–826) [39–1639] | 1056 (829–1439) [147–4244] | < 0.0001*p |
E2 hcg day (pg/ml) | 1538 (1043–2391) [300–7845] | 2561 (1600–3238) [482–7793] | 0.001* |
Progesterone at hCG day (ng/ml) | 0.8 (0.6–1.1) [0.17–2.5] | 0.86 (0.6–1.37) [0.2–4.9] | 0.183* |
Endometrial thickness (mm) | 9.5 (8.6–10.7) [6.7–13] | 10 (8.7–10.9) [7.3–15.3] | 0.25* |
N. oocytes retrieved | 6 (5–8) [3–17] | 6 (5–9) [3–17] | 0.361* |
N. MII oocytes | 5 (4–7) [2–12] | 5 (4–7) [2–14] | 0.593* |
hCG day E2/follicles > 16 mm ratio | 193 (128–292) [28–569] | 320 (219–434) [87–974] | < 0.0001p |
hCG day E2/total oocyte ratio | 233 (169–329([53–590] | 372 (309–660) [116–1025] | 0.001p |
hCG E2/MII oocytes ratio | 313 (221–430) [60–1077] | 473 (309–660) [120–1025] | 0.001p |
N. embryos | 3 (2–4) [1–12] | 3 (2–3) [1–9] | 0.895* |
N. good quality embryos | 2 (2–3) [0–8] | 2 (1.5–3) [0–5] | 0.864* |
N. transferred embryos | 2 (2–3) [1–3] | 2 (2–3) [0–3] | 0.605* |
N. good quality embryos transferred | 2 (1–2) [0–3) | 2 (1–2) [0–3] | 0.815* |
N. fresh cycles (%) | 80 | 60 | 0.016# |
Fertilization rate (%) | 78.9 | 79.9 | 0.941# |
Pregnancy rate in fresh cycles N (%) | 33/64 (51) | 10/36 (27.7) | 0.021§ |
Clinical pregnancy rate in fresh cycles N (%) | 30/64 (46.8) | 10/36 (27.7) | 0.061§ |
Cumulative pregnancy rates (fresh + cryo) N (%) | 36/80 (48.7) | 12/45 (26.6) | 0.016§p |
Cumulative clinical pregnancy rate N(%) | 34/80 (42.5) | 11/45 (24.4) | 0.044§ |