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Table 2 Stimulation and IVF outcome variables of PCOS patients under letrozole plus HMG or HMG-only stimulation protocol

From: Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study

  Group 1 (Let-HMG) Group 2 (HMG) p-value
Days of stimulation (N) 11 (10–12) [8–15] 10 (10–12) [9–15] 0.246*
HMG dose (units) 1350 (1200–1500) [626–2475] 1800 (1337–3110) [1050–5325] < 0.0001*p
E2 day 5 (pg/ml) 103 (73–182) [14–495] 525 (284–703) [82–1328] < 0.0001*p
E2 day 8 (pg/ml) 502 (322–826) [39–1639] 1056 (829–1439) [147–4244] < 0.0001*p
E2 hcg day (pg/ml) 1538 (1043–2391) [300–7845] 2561 (1600–3238) [482–7793] 0.001*
Progesterone at hCG day (ng/ml) 0.8 (0.6–1.1) [0.17–2.5] 0.86 (0.6–1.37) [0.2–4.9] 0.183*
Endometrial thickness (mm) 9.5 (8.6–10.7) [6.7–13] 10 (8.7–10.9) [7.3–15.3] 0.25*
N. oocytes retrieved 6 (5–8) [3–17] 6 (5–9) [3–17] 0.361*
N. MII oocytes 5 (4–7) [2–12] 5 (4–7) [2–14] 0.593*
hCG day E2/follicles > 16 mm ratio 193 (128–292) [28–569] 320 (219–434) [87–974] < 0.0001p
hCG day E2/total oocyte ratio 233 (169–329([53–590] 372 (309–660) [116–1025] 0.001p
hCG E2/MII oocytes ratio 313 (221–430) [60–1077] 473 (309–660) [120–1025] 0.001p
N. embryos 3 (2–4) [1–12] 3 (2–3) [1–9] 0.895*
N. good quality embryos 2 (2–3) [0–8] 2 (1.5–3) [0–5] 0.864*
N. transferred embryos 2 (2–3) [1–3] 2 (2–3) [0–3] 0.605*
N. good quality embryos transferred 2 (1–2) [0–3) 2 (1–2) [0–3] 0.815*
N. fresh cycles (%) 80 60 0.016#
Fertilization rate (%) 78.9 79.9 0.941#
Pregnancy rate in fresh cycles N (%) 33/64 (51) 10/36 (27.7) 0.021§
Clinical pregnancy rate in fresh cycles N (%) 30/64 (46.8) 10/36 (27.7) 0.061§
Cumulative pregnancy rates (fresh + cryo) N (%) 36/80 (48.7) 12/45 (26.6) 0.016§p
Cumulative clinical pregnancy rate N(%) 34/80 (42.5) 11/45 (24.4) 0.044§
  1. Data are displayed as median with upper and lower range in round parentheses and ranges in squared parentheses, or as count with percentages in parentheses
  2. *Two-tailed Mann-Whitney test
  3. #2-sided Pearson Chi-square test
  4. §Z-test for two independent proportions
  5. pthe study is powered to detect this difference