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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage

Fig. 6

A schematic mechanism of ERS in CDDP-induced ovarian damage. Exogenous CDDP increases the accumulation misfolded proteins in ER in granulosa cells, which subsequently enhance HSPA5 and HSP90AB1 expressions, leading to activation of ERS. ERS promotes cell autophagy and apoptosis. Excessive granulosa cell apoptosis induces follicular atresia contributing to ovarian dysfunction. 4-PBA can alleviate ERS, suppress cell autophagy and apoptosis, preserve follicles, and thus prevent against CDDP-induced ovarian damage

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