Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study

Table 4 Associations between fetal genotypes and candidate lipid species’ peak intensity

SNP	Gene	Parental Transmission	Lipid	VIP Score of lipid species*	Discovery Cohort			Validation Cohort			Meta-Analysis
SNP	Gene	Parental Transmission	Lipid	VIP Score of lipid species*	R	p-value	n	R	p-value	n	R	p-value
rs10839220	KRTAP5–6	Maternal	TG(44:1)	3.4	0.175	0.03	163	0	0.96	197	0.09 (− 0.09, 0.25)	0.17
rs10839220	KRTAP5–6	Maternal	LysoPCP(18:0)	2.8	0.243	1.8 × 10^− 3	163	0.092	0.16	233	0.16 (0.01, 0.31)	0.02
rs10839220	KRTAP5–6	Maternal	PE(34:0)	2.2	0.279	3.2 × 10⁻⁴	163	0.014	0.85	233	0.15 (−0.12, 0.39)	0.14
rs10839220	KRTAP5–6	Maternal	DG(36:3)	2.1	0.271	4.6 × 10⁻⁴	163	0.118	0.09	209	0.19 (0.04, 0.34)	7.4 × 10⁻³
rs4752779	FAM99B	Maternal	TG(44:1)	3.2	0.161	0.03	173	0.030	0.67	201	0.09 (−0.04, 0.22)	0.08
rs7131362	FAM99A	Maternal	TG(44:1)	4.7	0.257	9.7 × 10⁻⁴	161	0.114	0.12	190	0.18 (0.04, 0.32)	6.2 × 10⁻³
rs7131362	FAM99A	Maternal	TG(48:0)	2.1	0.197	0.01	161	0	0.95	217	0.10 (−0.10, 0.28)	0.17
rs17073273	PLAGL1	Maternal	TG(44:1)	3.5	0.181	0.02	175	0.014	0.83	206	0.09 (−0.07, 0.25)	0.13
rs17073273	PLAGL1	Maternal	TG(55:9)	2.7	0.234	1.8 × 10⁻³	175	0.079	0.23	235	0.15 (0.00, 0.30)	0.03
rs17073273	PLAGL1	Maternal	TG(48:0)	2.5	0.226	2.6 × 10⁻³	175	0.035	0.59	235	0.13 (−0.06, 0.31)	0.09
rs2268445	PLAGL1	Maternal	TG(44:1)	3.6	0.189	0.01	176	0.035	0.62	212	0.11 (−0.04, 0.26)	0.08
rs7950932	H19	Paternal	TG(44:1)	2.6	0.167	0.02	183	0.117	0.10	203	0.14 (0.04, 0.24)	2.3 × 10⁻³

Only those lipid species that tagged components with significant fitted models in Metaboanalyst are shown
*in the PLSDA component with a significant Q² in the Discovery Cohort dataset

ISSN: 1477-7827