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Table 4 Associations between fetal genotypes and candidate lipid species’ peak intensity

From: Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study

SNP Gene Parental Transmission Lipid VIP Score of lipid species* Discovery Cohort Validation Cohort Meta-Analysis
R p-value n R p-value n R p-value
rs10839220 KRTAP5–6 Maternal TG(44:1) 3.4 0.175 0.03 163 0 0.96 197 0.09 (− 0.09, 0.25) 0.17
rs10839220 KRTAP5–6 Maternal LysoPCP(18:0) 2.8 0.243 1.8 × 10− 3 163 0.092 0.16 233 0.16 (0.01, 0.31) 0.02
rs10839220 KRTAP5–6 Maternal PE(34:0) 2.2 0.279 3.2 × 10−4 163 0.014 0.85 233 0.15 (−0.12, 0.39) 0.14
rs10839220 KRTAP5–6 Maternal DG(36:3) 2.1 0.271 4.6 × 10−4 163 0.118 0.09 209 0.19 (0.04, 0.34) 7.4 × 10−3
rs4752779 FAM99B Maternal TG(44:1) 3.2 0.161 0.03 173 0.030 0.67 201 0.09 (−0.04, 0.22) 0.08
rs7131362 FAM99A Maternal TG(44:1) 4.7 0.257 9.7 × 10−4 161 0.114 0.12 190 0.18 (0.04, 0.32) 6.2 × 10−3
rs7131362 FAM99A Maternal TG(48:0) 2.1 0.197 0.01 161 0 0.95 217 0.10 (−0.10, 0.28) 0.17
rs17073273 PLAGL1 Maternal TG(44:1) 3.5 0.181 0.02 175 0.014 0.83 206 0.09 (−0.07, 0.25) 0.13
rs17073273 PLAGL1 Maternal TG(55:9) 2.7 0.234 1.8 × 10−3 175 0.079 0.23 235 0.15 (0.00, 0.30) 0.03
rs17073273 PLAGL1 Maternal TG(48:0) 2.5 0.226 2.6 × 10−3 175 0.035 0.59 235 0.13 (−0.06, 0.31) 0.09
rs2268445 PLAGL1 Maternal TG(44:1) 3.6 0.189 0.01 176 0.035 0.62 212 0.11 (−0.04, 0.26) 0.08
rs7950932 H19 Paternal TG(44:1) 2.6 0.167 0.02 183 0.117 0.10 203 0.14 (0.04, 0.24) 2.3 × 10−3
  1. Only those lipid species that tagged components with significant fitted models in Metaboanalyst are shown
  2. *in the PLSDA component with a significant Q2 in the Discovery Cohort dataset