Subgroup | N | SEN (95% CI) | SPE (95% CI) | PLR (95% CI) | NLR (95% CI) | DS (95% CI) | DOR (95% CI) | AUC (95% CI) | P a | |
---|---|---|---|---|---|---|---|---|---|---|
Overall | 12 | 0.57 (0.41–0.71) | 0.85 (0.73–0.93) |
3.91 (2.31–6.61) |
0.50 (0.37–0.68) | 2.05 (1.43–2.67) | 7.78 (4.19–14.46) | 0.78 (0.74–0.81) | ||
Outlier excluded | 11 | 0.51 (0.39–0.62) | 0.88 (0.79–0.94) |
4.22 (2.42–7.36) |
0.56 (0.45–0.69) | 2.02 (1.37–2.67) | 7.53 (3.92–14.47) | 0.73 (0.69–0.77) | ||
Storage method | ||||||||||
Cryopreservation | 1 | 0.51 | 0.51 | 1.06 | 0.95 | −c | 1.12 | – | < 0.001 | |
Fresh | 11 | 0.60 (0.41–0.76) | 0.87 (0.77–0.93) | 4.64 (3.04–7.08) | 0.46 (0.32–0.68) | 2.30 (1.80–2.80) | 9.99 (6.05–16.49) | 0.83 (0.80–0.86) | ||
Preparation method | ||||||||||
No preparation | 6 | 0.72 (0.50–0.87) | 0.80 (0.59–0.92) | 3.68 (1.90–7.13) | 0.35 (0.21–0.59) | 2.36 (1.71–3.01) | 10.56 (5.51–20.26) | 0.83 (0.79–0.86) | 0.006 | |
Swim up | 4b | 0.38 (0.24–0.54) | 0.86 (0.49–0.97) | 2.63 (0.75–9.18) | 0.73 (0.62–0.85) | 1.29 (− 0.06–2.63) | 3.62 (0.94–13.90) | 0.51 (0.47–0.56) | ||
Discontinuous gradient | 4 | 0.46 (0.28–0.65) | 0.90 (0.87–0.93) | 4.83 (2.64–8.83) | 0.60 (0.41–0.87) | 2.09 (1.14–3.04) | 8.08 (3.13–20.88) | 0.90 (0.87–0.92) | ||
FR cut-off value combined with AE assay method | ||||||||||
< 50% | Spectrophotometry | NC | ||||||||
Spectrophotometry/BAPNA | 4b | 0.63 (0.48–0.76) | 0.87 (0.60–0.97) | 4.96 (1.51–16.37) | 0.42 (0.32–0.57) | 2.46 (1.24–3.67) | 11.68 (3.47–39.36) | 0.75 (0.71–0.79) | ||
Substrate assay | ||||||||||
Acrosin target with gelatine substrate assay | 1 | 0.50 | 0.93 | 7.00 | 0.54 | – | 13.00 | 0.80d | ||
≤ 50% | Substrate assay | |||||||||
Acrosin target with gelatine substrate assay | 1 | 0.26 | 0.97 | 9.64 | 0.76 | – | 12.63 | – | ||
= 0% | Fluorometry | |||||||||
PAb-acrosin | 1 | 0.63 | 0.92 | 9.23 | 0.39 | – | 23.87 | – | ||
PAb-hyaluronidase | 1 | 0.23 | 0.90 | 2.29 | 0.86 | – | 2.68 | – | ||
MAb 4D4-proacrosin | 1 | 0.40 | 0.96 | 10.00 | 0.63 | – | 16.00 | 0.71d | ||
Spectrophotometry | ||||||||||
Spectrophotometry/BAPNA | 4 | 0.78 (0.38–0.95) | 0.63 (0.40–0.81) | 2.11 (1.25–3.55) | 0.35 (0.11–1.18) | 1.78 (0.29–3.27) | 5.94 (1.34–26.34) | 0.74 (0.70–0.78) | ||
Accu-sperm Spectrophotometry/BAPNA | 1 | 0.61 | 0.84 | 3.90 | 0.46 | – | 8.4 | – |