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Table 5 Summary of Rs values for AE assay

From: Human sperm acrosome function assays are predictive of fertilization rate in vitro: a retrospective cohort study and meta-analysis

Subgroup N Rs (95% CI) Test(s) of heterogeneity Significance test(s) of Rs = 0 P a
I2 (%) P Z P  
Overall 13 0.39 (0.18–0.60) 95.7 0.000 3.70 0.000  
Two experiments excluded 11 0.38 (0.27–0.48) 67.1 0.001 7.19 0.000  
Geographic area
 Asia 4 0.24 (0.05–0.42) 66.7 0.029 2.49 0.013 < 0.001
 North America 1 0.54 (0.43–0.65) b 9.70 0.000  
 Europe 6 0.46 (0.37–0.54) 0.0 0.798 11.02 0.000  
Preparation method
 No preparation 6 0.42 (0.30–0.55) 63.4 0.018 6.72 0.000 0.04
 Swim up 3 0.27 (0.01–0.53) 80.6 0.006 2.01 0.044  
 Discontinuous gradient 2 0.42 (0.23–0.60) 0.0 0.893 4.41 0.000  
AE assay method
 Fluorometry
  MAb 4D4-proacrosin 1 0.49 (0.27–0.70) 4.43 0.000 < 0.001
 Spectrophotometry
  Spectrophotometry/BAPNA 5 0.44 (0.35–0.54) 0.0 0.618 9.08 0.000  
  Accu-Sperm spectrophotometry/BAPNA 2 0.09 (−0.05–0.23) 0.0 0.352 1.22 0.223  
 Substrate assay
  Acrosin target with gelatine substrate assay 2 0.43 (0.30–0.56) 0.0 0.997 6.51 0.000  
  Hyaluronidase target with agar/hyaluronic acid mixture substrate assay 1 0.54 (0.43–0.65) 9.70 0.000  
  1. Rs spearman correlation coefficient, CI confidence interval, BAPNA N-α-benzoyl-dl-arginine-p-nitroanilide
  2. aComparison between subgroups with the Q test for heterogeneity
  3. bNot calculated