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Table 2 CC expression of the studied genes regarding clinical variables and development into eRBs and TQ + GQs

From: Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?

 

eRB

TQ + GQ

p

OR (95% CI)

p

OR (95% CI)

TNFAIP6

Age

0.790

0.996 (0.965, 1.028)

0.178

0.979 (0.948, 1.010)

BMI

0.837

1.005 (0.957, 1.055)

0.324

1.025 (0.976, 1.075)

AMH

0.195

1.045 (0.977, 1.118)

0.043*

1.083 (1.003, 1.169)

aFollicle size (large)

< 0.001**

2.146 (1.760, 2.617)

< 0.001**

1.877 (1.512, 2.329)

TNFAIP6

0.438

1.001 (0.997, 1.005)

0.081

0.988 (0.974, 1.002)

PTGS2

Age

0.817

0.996 (0.966, 1.027)

0.179

0.979 (0.950, 1.010)

BMI

0.976

1.001 (0.953, 1.051)

0.435

1.019 (0.971, 1.070)

AMH

0.214

1.043 (0.975, 1.116)

0.060

1.076 (0.997, 1.160)

aFollicle size (large)

< 0.001**

2.147 (1.760, 2.618)

< 0.001**

1.863 (1.503, 2.308)

PTGS2

0.439

0.966 (0.887, 1.054)

0.670

0.978 (0.881, 1.085)

PTX3

Age

0.873

0.997 (0.966, 1.029)

0.084

0.973 (0.943, 1.004)

BMI

0.831

0.995 (0.948, 1.044)

0.492

1.017 (0.969, 1.068)

AMH

0.149

1.051 (0.982, 1.126)

0.026*

1.089 (1.010, 1.174)

aFollicle size (large)

< 0.001**

2.162 (1.751, 2.671)

< 0.001**

1.880 (1.506, 2.346)

PTX3

0.720

0.698 (0.097, 4.998)

0.847

0.831 (0.126, 5.446)

HAS2

Age

0.831

0.997 (0.967, 1.028)

0.147

0.978 (0.949, 1.008)

BMI

0.982

1.001 (0.954, 1.050)

0.401

1.021 (0.973, 1.070)

AMH

0.163

1.048 (0.981, 1.120)

0.037*

1.081 (1.005, 1.163)

aFollicle size (large)

< 0.001**

2.120 (1.741, 2.582)

< 0.001**

1.859 (1.504, 2.297)

HAS2

0.511

0.995 (0.982, 1.009)

0.043*

0.955 (0.913, 0.998)

GDF9

Age

0.785

0.995 (0.960, 1.031)

0.208

0.976 (0.939, 1.014)

BMI

0.715

0.990 (0.937, 1.045)

0.348

1.027 (0.971, 1.085)

AMH

0.103

1.078 (0.985, 1.180)

0.067

1.088 (0.994, 1.190)

aFollicle size (large)

< 0.001**

2.145 (1.683, 2.734)

< 0.001**

1.913 (1.461, 2.505)

GDF9

0.912

1.001 (0.987, 1.015)

0.049*

0.975 (0.952, 0.999)

  1. (Studied genes are: tumour necrosis factor alpha induced protein 6 (TNFAIP6), prostaglandin-endoperoxide synthase 2 (PTGS2), hyaluronan synthase 2 (HAS2), pentraxin-related protein 3 (PTX3) and growth differentiation factor 9 (GDF9)). Embryos reaching blastocyst stage (eRB); top (TQ) or good quality (GQ) blastocysts
  2. *p < 0.05; **p < 0.01
  3. aSmall follicular size was selected as a reference category