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Table 1 CC gene expression levels regarding follicular size and embryo development on day5

From: Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?

Concentrations

TNFAIP6

PTGS2

HAS2

PTX3

GDF9

Mean (se)

Mean (se)

Mean (se)

Mean (se)

Mean (se)

Follicular size

n

1195

1205

1212

1110

742

Small

0.629 (0.564)

0.281 (0.027)

0.631 (0.287)

0.011 (0.004)

1.075 (0.297)

n

1061

1066

1072

975

648

Large

0.956 (0.784)

0.434 (0.047)

0.922 (0.350)

0.014 (0.003)

0.997 (0.255)

pa

0.204

< 0.001**

0.193

0.371

0.847

eRB

n

472

478

482

439

295

Small

1.163 (1.065)

0.284 (0.027)

0.710 (0.339)

0.010 (0.003)

1.217 (0.533)

n

605

609

612

559

370

Large

0.790 (0.637)

0.399 (0.038)

0.811 (0.356)

0.013 (0.003)

0.966 (0.347)

pa

0.451

< 0.001**

0.036*

0.344

0.701

eFRB

n

723

727

730

671

447

Small

0.235 (0.245)

0.270 (0.031)

0.538 (0.254)

0.013 (0.006)

0.987 (0.356)

n

456

457

460

416

278

Large

1.376 (1.193)

0.480 (0.082)

1.172 (0.562)

0.016 (0.005)

1.047 (0.383)

pa

0.274

0.010*

0.249

0.266

0.911

TQ or GQ Blastocysts

n

253

258

260

237

151

Small

0.726 (0.506)

0.275 (0.031)

0.514 (0.127)

0.011 (0.003)

0.415 (0.323)

n

349

353

354

325

212

Large

0.727 (0.506)

0.388 (0.040)

0.562 (0.126)

0.013 (0.005)

0.410 (0.211)

pa

0.562

0.002**

0.060

0.714

0.956

Arrested embryos or BQ Blastocysts

n

942

947

952

873

591

Small

0.684 (0.631)

0.274 (0.030)

0.649 (0.345)

0.011 (0.004)

1.243 (0.361)

n

712

713

718

650

436

Large

0.978 (0.841)

0.445 (0.059)

1.001 (0.414)

0.013 (0.003)

1.282 (0.369)

pa

0.217

0.003**

0.323

0.466

0.942

  1. Studied genes are: tumour necrosis factor alpha induced protein 6 (TNFAIP6), prostaglandin-endoperoxide synthase 2 (PTGS2), hyaluronan synthase 2 (HAS2), pentraxin-related protein 3 (PTX3) and growth differentiation factor 9 (GDF9)
  2. eRB embryos reaching blastocyst, eFRB embryos failed to reach blastocyst, TQ top quality blastocyst, GQ good quality blastocyst, BQ bad quality blastocyst
  3. **p < 0.01; *p<0.05
  4. aGLMM (Generalized linear mixed model) se: standard error