FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

Table 4 FMR1 mRNA gene expression levels in different FMR1 genotype and ovarian response groups (age-independent)

FMR1 Expression	high/high		high/low		high/normal		normal/normal		normal/low		low/low		p value
FMR1 Expression	n	(P25-P75)	n	(P25-P75)	n	(P25-P75)	n	(P25-P75)	n	(P25-P75)	n	(P25-P75)	p value
All patients	1^a	0.309	3	0.32 (0.26–1.54)	21	0.67 (0.51–1.21)	109	0.73 (0.47–1.25)	59	0.84 (0.55–1.27)	8	0.68 (0.19–1.69)	0.475
NOR	1^a	0.309	3	0.32 (0.26–1.54)	10	0.95 (0.53–1.47)	71	0.71 (0.48–1.25)	45	0.77 (0.52–1.09)	6	0.68 (0.16–1.9)	0.630
POR	0	–	0	–	9	0.56 (0.47–0.69)	32	0.78 (0.43–1.2)	14	1.1 (0.95–1.5)	2	0.77 (0.2–1.3)	0.044
PCO	0	–	0	–	2	1.05 (0.92–1.19)	6	0.83 (0.35–1.53)	0	–	0	–	0.505

Distribution of FMR1-expression in GCs among the six genotypes related to different ovarian response groups. Normal/low genotypes demonstrated elevated FMR1 expression in case of poor response (p = 0.044)
^aDescriptive analysis only, due to the number of patients
p values represent significance-levels between the six genotypes and are calculated as described in the Material and Method part

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