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Table 2 Cohort demographic analysis of groups formed according to FMR1 genotypes

From: FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

 

All patients

Demographics

high/high

high/low

high/normal

normal/normal

normal/low

low/low

p value

n

(P25-P75)

n

(P25-P75)

n

(P25-P75)

n

(P25-P75)

n

(P25-P75)

n

(P25-P75)

Agea

2

34 ± 5.6

3

28.6 ± 1.1

25

35.4 ± 4.4

123

35.7 ± 4.5

65

35.9 ± 4.7

8

36.3 ± 3.2

0.163

AFC

2

6 (6–6)

0

–

18

3 (1.8–7.1)

62

5.75 (3–9.12)

38

5 (3–6.1)

3

5.5 (3.5–10)

0.239

FSH

2

9.5 (6.6–12.4)

2

7.3 (6.9–7.7)

23

8.3 (6.1–10.9)

110

7.1 (5.7–8.7)

56

7.8 (6.2–9.3)

7

7.9 (5.2–10.3)

0.323

LH

2

9.2 (6.7–11.7)

3

4.8 (4.7–6.1)

24

5.7 (3.7–10.1)

113

5.4 (3.5–7.1)

56

5.3 (3.7–6.4)

8

4.9 (3.6–6)

0.338

Estradiol

2

55.8 (51.5–68.2)

3

47.3 (31.2–63.1)

23

45.6 (38.2–76)

108

40.6 (32.4–58.2)

54

43.6 (34.3–57.9)

7

55.7 (41.5–76)

0.372

AMH

2

1.24 (0.94–1.55)

2

2.49 (2.48–2.5)

25

0.88 (0.55–3.35)

120

1.86 (1.06–3.68)

59

1.87 (1.14–3.16)

8

1.37 (1.03–1.64)

0.426

Total oocyte number

2

2.5 (2–3)

3

9 (7–14)

23

6 (2–14)

120

7 (4–12)

63

7 (5–12)

8

4.5 (3.2–6)

0.210

MII oocyte number

2

2 (2–2)

2

6.5 (6–7)

16

6 (2–15)

92

6 (3–9)

49

6 (4.5–9)

5

5 (3–8.5)

0.739

  1. BMI body mass index, AFC antral follicle count, FSH follicle stimulating hormone, LH luteinizing hormone, AMH anti-Müllerian-hormone, MII oocytes mature oocytes.
  2. aAge, mean ± standard deviation is presented
  3. All other values are presented as median and 1st and 3rd quartile parenthesized
  4. p values represent significance levels between the six evaluated FMR1 genotypes