FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve

Table 1 Cohort demographics

Demographic	NOR		POR		PCO		p value
Demographic	n	Median (P25-P75)	n	Median (P25-P75)	n	Median (P25-P75)	p value
Age*	151	35.1 ± 4.2^A	70	37.4 ± 4.6^B	8	31.3 ± 3.8^C	0.001
BMI	149	23.6 (20.5–27.3)	65	22.3 (20.7–25.4)	8	26.3 (20.9–32.1)	0.352
AFC	84	6 (4.5–9)^A	35	2.5 (1.5–3.5)^B	6	16.25 (12.1–20)^C	< 0.001
FSH (U/L)	137	7.2 (6–8.8)^A	59	8.6 (6.1–11.1)^B	7	6.1 (5.8–7.2)^AB	0.013
LH (U/L)	139	5.3 (3.7–6.8)^A	62	5.5 (3.5–6.5)^A	8	12.9 (9.6–17.5)^B	< 0.001
Estradiol	133	43 (34.5–58.2)	59	49.2 (31.1–76.0)	8	41.7 (31.1–46.4)	0.810
AMH	142	2.47 (1.4–3.8)^A	69	0.88 (0.5–1.1)^B	8	9.37 (4.5–14.6)^C	< 0.001
Total oocytes	149	9 (6–13)^A	64	3 (2–5.7)^B	8	22 (4.2–36)^A	< 0.001
MII oocytes	117	7 (5–11)^A	43	3 (2–5)^B	6	16 (8–27.2)^A	< 0.001
FMR1	138	0.75 (0.5–1.2)	57	0.8 (0.5–1.2)	8	0.9 (0.46–1.43)	0.947

BMI body mass index, AFC antral follicle count, FSH follicle stimulating hormone, LH luteinizing hormone, AMH anti-Müllerian-hormone, MII oocytes, mature oocytes, FMR1 fragile X mental retardation 1 gene relative gene expression in granulosa cells of the patients normalized by two house-keeping genes and a granulosa cell calibrator (see MM-part for details)
All other values represent median values, with 1st and 3rd quartile parenthesized
Different letters in one row signify statistical difference
p values represent significance levels between normal responders (NOR), poor responders (POR), and polycystic ovarian syndrome group (PCO)
*Mean ± standard deviation

ISSN: 1477-7827