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Table 4 Effects of Mmp9 and Pappa2 deletion on fetal mass and placental mass in pregnancies segregating for Mmp9

From: PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

  Term in model
  Mmp9 Pappa2 Mmp9*Pappa2 interaction Number of fetuses Sex of fetus
G16
  F1,16 P F1,18 P F1,16 P F1,18 P F1,15 P
Fetal mass 9.69 0.007 0.07 0.80 0.40 0.54 2.97 0.10 14.72 0.002
Placental mass 12.63 0.003 0.06 0.80 0.01 0.91 5.12 0.04 31.08 0.0001
G18
  F1,10 P F1,11 P F1,10 P F1,11 P F1,11 P
Fetal mass 9.53 0.012 0.59 0.46 0.03 0.88 7.24 0.02 1.06 0.32
Placental mass 0.81 0.39 1.13 0.31 1.26 0.29 4.49 0.06 17.82 0.0014
  1. These analyses included multiple conceptuses per dam, and so statistics are from repeated measures analyses (with dam as a random factor), including effects of Mmp9 genotype of conceptus (Mmp9−/− vs. Mmp9+/− and Mmp9+/+), Pappa2 deletion (whether the cross included at least one functional Pappa2 allele or not), the interaction between these two factors, fetal sex, and the number of fetuses as a covariate