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Table 4 Effects of Mmp9 and Pappa2 deletion on fetal mass and placental mass in pregnancies segregating for Mmp9

From: PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

 

Term in model

 

Mmp9

Pappa2

Mmp9*Pappa2 interaction

Number of fetuses

Sex of fetus

G16

 

F1,16

P

F1,18

P

F1,16

P

F1,18

P

F1,15

P

Fetal mass

9.69

0.007

0.07

0.80

0.40

0.54

2.97

0.10

14.72

0.002

Placental mass

12.63

0.003

0.06

0.80

0.01

0.91

5.12

0.04

31.08

0.0001

G18

 

F1,10

P

F1,11

P

F1,10

P

F1,11

P

F1,11

P

Fetal mass

9.53

0.012

0.59

0.46

0.03

0.88

7.24

0.02

1.06

0.32

Placental mass

0.81

0.39

1.13

0.31

1.26

0.29

4.49

0.06

17.82

0.0014

  1. These analyses included multiple conceptuses per dam, and so statistics are from repeated measures analyses (with dam as a random factor), including effects of Mmp9 genotype of conceptus (Mmp9−/− vs. Mmp9+/− and Mmp9+/+), Pappa2 deletion (whether the cross included at least one functional Pappa2 allele or not), the interaction between these two factors, fetal sex, and the number of fetuses as a covariate
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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