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Table 2 Effects of Mmp9 and Pappa2 deletion on fertility including F2 and BC females, i.e., females collected at G16 or G18

From: PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

  No wild-type Pappa2 alleles
Mmp9 mating type
At least one wild-type Pappa2 allele
Mmp9 mating type
  0–1 2–4 0–1 2–4
# matings for pregnancya 2.3 ± 0.4 2.3 ± 0.3 2.7 ± 0.3 2.9 ± 0.3
# females that became pregnant 11 16 19 17
# females that did not become pregnant 2 9 7 6
# females with no failed matingsb 9 18 18 19
# females with failed matingb 4 7 8 4
  1. aLeast-squares means ± standard error from a general linear model including Mmp9 mating type, whether mating had any wild-type Pappa2 alleles, and the interaction between these two terms
  2. bA failed mating was defined as when a vaginal plug was detected following mating, but pregnancy did not develop; this analysis includes females that subsequently became pregnant, and those that never became pregnant