PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

Table 2 Effects of Mmp9 and Pappa2 deletion on fertility including F2 and BC females, i.e., females collected at G16 or G18

	No wild-type Pappa2 alleles Mmp9 mating type		At least one wild-type Pappa2 allele Mmp9 mating type
	0–1	2–4	0–1	2–4
# matings for pregnancy^a	2.3 ± 0.4	2.3 ± 0.3	2.7 ± 0.3	2.9 ± 0.3
# females that became pregnant	11	16	19	17
# females that did not become pregnant	2	9	7	6
# females with no failed matings^b	9	18	18	19
# females with failed mating^b	4	7	8	4

^aLeast-squares means ± standard error from a general linear model including Mmp9 mating type, whether mating had any wild-type Pappa2 alleles, and the interaction between these two terms
^bA failed mating was defined as when a vaginal plug was detected following mating, but pregnancy did not develop; this analysis includes females that subsequently became pregnant, and those that never became pregnant

ISSN: 1477-7827