Fig. 1

The hormone determination in wild type (WT) and Y123F homozygous (Y123F) mice. The FSH, LH, T, E2, P and leptin levels in wild type and Y123F homozygous mouse blood were determined. a The blood FSH levels in WT (n = 8) were significantly higher than Y123F (n = 9) mice (p < 0.05). b The blood LH levels in WT (n = 7) were significantly higher than Y123F (n = 9) mice (p < 0.05). c The blood T levels in WT (n = 5) were significantly lower than Y123F (n = 5) mice (p < 0.01). d The blood leptin levels in WT (n = 7) were significantly lower than Y123F (n = 9) mice (p < 0.01). e The blood E2 levels in WT (n = 9/13) and Y123F (n = 7/6) mice after an intraperitoneal injection of 10 IU hFSH or PBS. f The blood P levels in WT (n = 5/8) and Y123F (n = 9/6) mice after an intraperitoneal injection of 10 IU hFSH or PBS. Data are expressed as the mean ± SD, *p < 0.05, **p < 0.01 indicate a significant difference between the WT and Y123F groups