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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice

Fig. 6

Gpr1 deficiency attenuates the effect of DHEA and Chemerin/GPR1 signaling modulates estradiol biosynthesis in granulosa cells with DHEA treatment through the mTOR signaling pathway. a DHEA treatment led to decreased ovarian steroidogenesis. Gpr1 deficiency improved steroidogenesis in ovaries. b Chemerin/GPR1 signaling modulates elevated estradiol secretion induced by DHEA through the mTOR signaling pathway to affect key enzymes involved in estradiol synthesis

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