Fig. 6From: Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized miceGpr1 deficiency attenuates the effect of DHEA and Chemerin/GPR1 signaling modulates estradiol biosynthesis in granulosa cells with DHEA treatment through the mTOR signaling pathway. a DHEA treatment led to decreased ovarian steroidogenesis. Gpr1 deficiency improved steroidogenesis in ovaries. b Chemerin/GPR1 signaling modulates elevated estradiol secretion induced by DHEA through the mTOR signaling pathway to affect key enzymes involved in estradiol synthesisBack to article page