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Table 2 Contraceptive effects of the recombinant proteins in the second mating test

From: The preclinical evaluation of immunocontraceptive vaccines based on canine zona pellucida 3 (cZP3) in a mouse model

Antigen Fertility rate (%) a Mean litter size b Average Abs levels P c
Adjuvant 100% (10/10) 6.1 ± 0.924 0.058 ± 0.003 d  
0.191 ± 0.018 e
OGZ 10% (1/10) 0.2 ± 0.2 0.691 ± 0.039 d ***
0.854 ± 0.176 e
OZ 50% (5/10) 2.5 ± 0.86 0.506 ± 0.073 d *
cZP3 50% (5/10) 2.6 ± 0.884 0.808 ± 0.047 d *
mZP3 50% (5/10) 2.7 ± 0.920 1.028 ± 0.084 d *
  1. aFertility rate: number of the fertile mice/total number of the mated mice in each group
  2. bMean litter size of mice: total number of the pups in each group/total number of the mated mice in each group
  3. cMean litter size in each group vs adjuvant group;* represents P < 0.05; ** represents P < 0.01;*** represents P < 0.005
  4. dAverage Abs levels of cZP3
  5. eAverage Abs levels of GnRH