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Table 2 Contraceptive effects of the recombinant proteins in the second mating test

From: The preclinical evaluation of immunocontraceptive vaccines based on canine zona pellucida 3 (cZP3) in a mouse model

Antigen

Fertility rate (%) a

Mean litter size b

Average Abs levels

P c

Adjuvant

100% (10/10)

6.1 ± 0.924

0.058 ± 0.003 d

 

0.191 ± 0.018 e

OGZ

10% (1/10)

0.2 ± 0.2

0.691 ± 0.039 d

***

0.854 ± 0.176 e

OZ

50% (5/10)

2.5 ± 0.86

0.506 ± 0.073 d

*

cZP3

50% (5/10)

2.6 ± 0.884

0.808 ± 0.047 d

*

mZP3

50% (5/10)

2.7 ± 0.920

1.028 ± 0.084 d

*

  1. aFertility rate: number of the fertile mice/total number of the mated mice in each group
  2. bMean litter size of mice: total number of the pups in each group/total number of the mated mice in each group
  3. cMean litter size in each group vs adjuvant group;* represents P < 0.05; ** represents P < 0.01;*** represents P < 0.005
  4. dAverage Abs levels of cZP3
  5. eAverage Abs levels of GnRH