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Table 1 Contraceptive effects of the recombinant proteins in the first mating test

From: The preclinical evaluation of immunocontraceptive vaccines based on canine zona pellucida 3 (cZP3) in a mouse model

Antigen Fertility rate (%)a Mean litter sizeb Average Abs levels P c
Adjuvant 100% (10/10) 7 ± 0.516 0.050 ± 0.004d  
0.183 ± 0.02e
OGZ 10% (1/10) 0.4 ± 0.4 2.092 ±0 .162 d ***
1.095 ± 0.056 e
OZ 50% (5/10) 2.3 ± 0.883 2.138 ±0 .334 d **
cZP3 50% (5/10) 2.2 ± 0.772 2.134 ±0 .103 d **
mZP3 40% (4/10) 2 ± 0.907 2.215 ±0 .156 d ***
  1. aFertility rate: number of the fertile mice/total number of the mated mice in each group
  2. bMean litter size of mice: total number of pups in each group/total number of the mated mice in each group
  3. cMean litter size in each group vs adjuvant group;* represents P < 0.05; ** represents P < 0.01; *** represents P < 0.005
  4. dAverage Abs levels of cZP3
  5. eAverage Abs levels of GnRH