Skip to main content
Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation

Fig. 2

Ovulatory cascade. LH/hCG induces PGE2 synthesis and secretion in cumulus cells. Additionally, granulosa cells under FSH stimulation release PGE2, which is coupled with PGT and transported to the cumulus cell membrane to bind the PGE2 receptors EP2 and EP4. Via these receptors, PGE2 induces MAPK phosphorylation, increases intracellular cAMP levels and activates the PKB/MAPK3/1 pathway to stimulate ovulatory gene expression. Furthermore, PGE2 stimulates Angiotensin II to inhibit the inhibitory factors against meiotic maturation, released by theca cells

Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us