Skip to main content
Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence

Fig. 7

Working model. Excessive NGF in the follicular fluid of PCOS patients. Stimulated-CCs secreted inhibitory factor(s) (undefined yet) and down-regulated the production of ODPFs in oocytes. Down-regulation of ODPFs could reduce glycolysis in CCs. Reduction of glycolysis in CCs impaired oocyte meiotic maturation at the antral follicle stage

Back to article page