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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence

Fig. 7

Working model. â‘  Excessive NGF in the follicular fluid of PCOS patients. â‘¡ Stimulated-CCs secreted inhibitory factor(s) (undefined yet) and down-regulated the production of ODPFs in oocytes. â‘¢ Down-regulation of ODPFs could reduce glycolysis in CCs. â‘£ Reduction of glycolysis in CCs impaired oocyte meiotic maturation at the antral follicle stage

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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