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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice

Fig. 1

Esmya, Duphaston and Dienogest suppress the growth and development of endometriotic lesions in mice. a Lesion size was measured by caliper at the end of intervention. Representative in situ pictures of the endometriotic lesions in vehicle, Esmya, Duphaston and Dienogest group are shown. Red arrows indicate the locations of the lesions. b Endometriotic lesion size and weight. Data are shown as mean ± SEM, n = 9 for each group, *: p < 0.05 when compared to the control group. c Histological change of lesions after medication. This panels show the representative cross-sections of the endometriotic lesion as endometrial cyst-like structure. Scar bar: 400um. d Proliferation of the endometriotic lesions. Representative pictures of immunohistochemical staining of Ki67 in endometriotic-like lesions in different groups after treatment. Scar bar: 200um. e Comparison of Ki67 positively stained epithelial and stroma cells in the lesions. f Representative pictures of TUNEL staining in endometriotic-like lesions in different groups after treatment. Scar bar: 200um. g Comparison of TUNEL positively cells in the lesions. Data are shown as mean ± SEM, n = 3 for each group, *: p < 0.05 when compared to the control group

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