Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China

Table 2 Non-parametric (Spearman) correlation coefficients (r) for relationships between sperm DFI and other parameters

Variables	Number	DFI
Variables	Number	r	P value
Age	1010	0.115	<0.001
BMI	1010	-0.051	0.108
WC	1010	-0.065	0.050
WHR	1010	-0.009	0.785
WHtR	1010	-0.057	0.068
Abstinence time	1010	0.171	<0.001
Semen volume	978	0.145	<0.001
Sperm concentration	978	-0.115	<0.001
Total sperm count	978	-0.054	0.091
Progressive motility	978	-0.474	<0.001
Sperm motility	978	-0.487	<0.001
Normal sperm morphology	978	-0.222	<0.001
TNPMS	978	-0.288	<0.001
Abnormal head	978	0.184	<0.001
Intact acrosome	978	-0.191	<0.001
Acrosomal enzyme activity	978	-0.307	<0.001
Seminal plasma total α-glucotase	959	0.089	0.057
Seminal plasma GGT	959	0.080	0.063
Seminal plasma fructose	959	0.002	0.957
Seminal plasma zinc	959	0.137	<0.001
Serum TG	974	0.026	0.411
Serum TC	974	-0.007	-0.820
Serum LDL	974	-0.005	-0.865
Serum HDL	974	0.008	0.814
Serum LH	954	0.134	<0.001
Serum FSH	954	0.113	<0.001
Serum estradiol	954	-0.039	0.234
Serum testosterone	954	-0.042	0.194
Serum SHBG	954	0.038	0.239
Seminal plasma TG	887	0.136	<0.001
Seminal plasma TC	887	0.131	<0.001
Seminal plasma LDL	887	0.013	0.695
Seminal plasma HDL	887	-0.064	0.058
Seminal plasma FSH	396	0.184	<0.001
Seminal plasma estradiol	396	0.099	0.048^*
Seminal plasma testosterone	396	-0.039	0.433

TNPMS Total normal-progressively motile spermatozoa count, SHBG sex hormone-binding globulin. *: P<0.05. Sperm DFI was positively related to age and abstinence time. Sperm DFI was also positively related to semen volume and the percentage of abnormal sperm head, while negatively related to sperm concentration, progressive motility, sperm motility, the percentage of normal sperm morphology, TNPMS, the percentage of intact acrosome sperm and acrosomal enzyme activity. Sperm DFI was positively related to seminal plasma zinc but unrelated to seminal plasma α-glucotase, GGT and fructose levels. There was no any significant correlation between sperm DFI and obesity-associated markers such as BMI, WC, WHR and WHtR, and serum lipids levels. However, sperm DFI was positively related to seminal plasma TG and TC levels. Sperm DFI was also positively related to serum LH and FSH levels and seminal plasma FSH and estradiol levels, but unrelated to serum and seminal plasma testosterone levels

ISSN: 1477-7827