Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial

Table 4 Clinical reproductive outcomes

Variable	Study group (n = 76)	Control group (n = 93)	p-value
Number of fresh ET cycles^a, n (%)	66/76 (86.84)	64/93 (68.82)	0.35
Patients who had oocyte retrieval but no ET ^b, n (%)	6/72 (8.33)	19/83 (22.89)	0.04
Number of FET cycles, n (%)	12/76 (15.79)	3/93 (3.23)	0.01
Patients with cryopreserved embryos, n (%)	14/76 (18.42)^c	4/93 (4.30)^d	0.012
Number of embryos per ET^e, median (IQR)	2 (1,2)	1 (1,2)	0.04
Clinical pregnancy rate per fresh ET^f, n (%)	23/66 (34.85)	16/64 (25.00)	0.24
Cumulative clinical pregnancy rate^g, n (%)	24/76 (31.58)	16/93 (17.20)	0.11
Multiple pregnancy, n (%)	4/76 (5.26)	3/93 (3.23)	0.70
Spontaneous miscarriage, n (%)	2/23 (8.67)	2/16 (12.50)	0.73
Live birth rate per fresh ET^f, n (%)	21/66 (31.82)	14/64 (21.88)	0.33
Cumulative live birth rate^g, n (%)	22/76 (28.95)	14/93 (15.54)	0.08

^aAll patients with available embryos had fresh ET
^bIncluded women who had hCG andoocyte retrieval but did not have oocytes or useable embryos
^cEmbryos for 2women from this group did not survive the thawing (2/14, 14.29%)
^dEmbryos for 1 woman from this group did not survive the thawing (1/4, 25%)
^eAll the transferred embryos were day-3 cleavage stage embryos
^fCalculated as follows: the number of clinical pregnancies/ live births originated from fresh ET divided by the number of women with transferred embryos
^gCalculated as follows: the number of clinical pregnancies/ live births originated from one completed ART cycle including fresh and frozen-thaw ETs divided by the number of women treated
ET – embryo transfer; FET – frozen-thaw embryo transfer; IQR – interquartile range