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Fig. 8 | Reproductive Biology and Endocrinology

Fig. 8

From: Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7

Fig. 8

TC-derived CXCL12 increased DEC invasion by binding to CXCR4 rather than CXCR7. a The addition of CXCL12 significantly increased the DECs invasion in vitro, while neutralizing antibody against CXCR4 or CXCL12 effectively inhibited the CXCL12-stimulated DEC invasion. The CXCR7 antibody failed to block the CXCL12-induced increase in DEC invasion. (n = 3). b Co-culture with TCs significantly increased DEC invasion in vitro, and a neutralizing antibody against CXCR4 or CXCL12 effectively inhibited the TC co-culture-stimulated DEC invasion. The CXCR7 antibody failed to block the TC co-culture-induced increase in DEC invasion. * P < 0.05, ** P < 0.01, compared to the control; # P < 0.01, compared to the CXCL12-treated group or TC co-culture group. Data are presented as average ± SEM. (n = 3)

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