Fig. 7

TC-derived CXCL12 induced DEC migration by binding to CXCR4 rather than CXCR7. a The addition of CXCL12 significantly increased DECs migration in vitro, while neutralizing antibodies to CXCR4 or CXCL12 effectively inhibited the CXCL12-stimulated DEC invasiveness. The CXCR7 antibody failed to block the CXCL12-induced increase in DEC migration. (n = 3). b Co-culture with TCs significantly increased the DECs migration in vitro, and a neutralizing antibody against CXCR4 or CXCL12 effectively inhibited the CXCL12-stimulated DEC migration. The CXCR7 antibody failed to block the TC co-culture-induced increase in DEC migration. * P < 0.05, ** P < 0.01, compared to the control; # P < 0.05, ## P < 0.01, compared to the CXCL12-treated group or TC co-culture group. Data are presented as average ± SEM. (n = 3)