Study aims | Dosage and duration | Study design/Subjects | Relevant study outcomes | Reference |
---|---|---|---|---|
Effects of LC and CrNic on ovulation and fertilization rates in gilts | 200 ppm LC + 200 ppb CrNic for 2 weeks prior to expected estrus | 105 gilts Positive controls were fed 11 lbs./day of complete diet (flushing) Treatment group was fed 4 lbs./day of diet with/without various treatments | Increased ovulation and fertilization rate | [20] |
Effects of dietary supplementation of LC and ascorbic acid in productive, reproductive, physiological and immunological performances of Golden Montazah aged breeder hens | 100 and 200 mg LC/kg diet + 1 g ascorbic acid for 4 weeks | 180 Golden Montazah hens + 18 cocks of 50 weeks old were randomly chosen. Birds were divided into 6 groups (each of 30 hens + 3 cocks), during the entire experimental period (from 50 to 70 weeks of age). | All groups fed diets of LC levels of 100 and 200 mg /kg diet alone and with 1 g ascorbic acid / kg diet were improved and recorded the best values of fertility and hatchability percentages. This improvement was increased with increasing LC level compared with the hens fed 1 g ascorbic acid /kg diet alone and the control group at the end of the experimental period. | [87] |
CoQ10 and LC co-treatment in ovulatory response in rabbits | 10 mg/kg CoQ10 + 40 mg/kg LC for 21 days | New Zealand White female rabbits of 5.3 months old | Higher ovulate rate, number of follicles, corpus luteum and increased number of embryos | [85] |
LC and vegetable oil supplementation in broiler breeder fertility | 60 ppm (females), 500 ppm (males) | – | In 5th and 6th week, egg production is increased with more cholesterol in egg yolk | [44] |
Dietary LC and choline chloride on reproductive indices in Holstein Dairy Cattle | 50Â g/day | From 1-week pre-calving to 4-weeks after parturition | Decreased SCC and improved other immune indices | [21] |
Both LC and ALC supplementations on ovulation and oocyte quality in CD1 mice | 0.4Â mg LC and 0.12Â mg ALC/mouse/day for 3Â weeks | Female CD1 mice of 8Â weeks old | Decreased percentage of oocyte degeneration with more developing oocytes | [47] |
NAC and LC on prevention of oocyte damage in women with mild endometriosis | 1.5 mM of NAC with 0.6 mg/mL LC in follicular fluid | In follicular fluid sample from infertile women with endometriosis aged less than 38 years who underwent ICSI and induced in bovine oocytes | LC and NAC combination prevented oocyte damage in mild endometriosis | [84] |
Effect of oral antioxidant and LC combination on IVF-ICSI outcomes | Vitamin C (180 mg), vitamin E (30 mg), zinc (15 mg), selenium (50 mg), LC tartarate (400 mg), folic acid (200 μg) and CoQ10 (40 mg) for 2 to 5 months at a daily dose of 2 capsules | Semen was taken for IVF and ICSI | • Enhanced semen quality • Improved sperm DNA integrity, fertilization rate, pregnancy rate, implantation rate, embryo quality as well as blastocyst development rate | [88] |
LC plus ALC on neuroendocrine control of hypothalamic functions in FHA | LC fumerate (863 mg), ALC (250 mg), vitamin-C (90 mg), N-acetyl cysteine (50 mg), vitamin E (30 mg), iron (7 mg), pantothenic acid (6 mg), zinc (5 mg), vitamin B6 (2 mg), copper (0.5 mg), β-carotene (4.8 mg), folic acid (200 μg), vitamin-D3 (5 μg), selenium (27.5 μg), vitamin B12 (2.5 μg) | 27 patients (aged 26.5 ± 2 years) with FHA for the last 6 months were subdivided into 2 groups: Group A (hypogonadotropic patients, plasma LH levels ≤3 mIU/ml, n = 15) Group B (normogonadotropic patients, plasma LH levels > 3 mIU/ml, n = 12) | • Carnitine administration significantly increases LH secretion in patients • Carnitine decreases cortisol and plasma amylase levels | [89] |