Skip to main content

Table 2 Predictive ability of NGS trophectoderm biopsy for miscarriage based on proportion of abnormal cells in the specimen

From: Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos

  Euploid < 20% Abnormal Mosaic ≥20% to ≤80% Abnormal p-value AUC
Miscarriage 75/736 10.2% 18/74 24.3% 0.0003 0.56
  Mosaic ≥20% to < 30% Abnormal Mosaic ≥30% to ≤80% Abnormal p-value AUC
Age Miscarriage
< 38 5/17 29.4% 9/31 29.0% 0.69 0.50
≥ 38 0/1 0.0% 4/25 16.0% 0.66 0.52
All Ages 5/18 27.8% 13/56 23.2% 0.69 0.52
  Mosaic ≥20% to < 40% Abnormal Mosaic ≥40% to ≤80% Abnormal p-value AUC
  Miscarriage   
< 38 11/33 33.3% 3/15 20.0% 0.35 0.57
≥ 38 2/12 16.7% 2/14 14.3% 0.87 0.52
All Ages 13/45 28.9% 5/29 17.2% 0.25 0.58
  Mosaic ≥20% to < 50% Mosaic Mosaic ≥50% to ≤80% Abnormal p-value AUC
Age Miscarriage
< 38 13/43 30.2% 1/5 20.0% 0.63 0.52
≥ 38 2/19 10.5% 2/7 28.6% 0.26 0.64
All Ages 15/62 24.2% 3/12 25.0% 0.95 0.50
  Mosaic ≥20% to < 60% Abnormal Mosaic ≥60% to ≤80% Abnormal p-value AUC
Age Miscarriage
< 38 14/48 29.2% 0/0 0.0%
≥ 38 2/20 10.0% 2/6 33.3% 0.16 0.66
All Ages 16/68 23.5% 2/6 33.3% 0.59 0.59
  Mosaic ≥20% to < 70% Abnormal Mosaic ≥70% to ≤80% Abnormal p-value AUC
Age Miscarriage
< 38 14/48 29.2% 0/0 0.0%
≥ 38 3/22 13.6% 1/4 25.0% 0.56 0.56
All Ages 17/70 24.3% 1/4 25.0% 0.97 0.50
  1. AUC: area under the curve