Reproductive Biology and Endocrinology

Table 2 Predictive ability of NGS trophectoderm biopsy for miscarriage based on proportion of abnormal cells in the specimen

From: Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos

	Euploid < 20% Abnormal		Mosaic ≥20% to ≤80% Abnormal		p-value	AUC
Miscarriage	75/736	10.2%	18/74	24.3%	0.0003	0.56
	Mosaic ≥20% to < 30% Abnormal		Mosaic ≥30% to ≤80% Abnormal		p-value	AUC
Age	Miscarriage				p-value	AUC
< 38	5/17	29.4%	9/31	29.0%	0.69	0.50
≥ 38	0/1	0.0%	4/25	16.0%	0.66	0.52
All Ages	5/18	27.8%	13/56	23.2%	0.69	0.52
	Mosaic ≥20% to < 40% Abnormal		Mosaic ≥40% to ≤80% Abnormal		p-value	AUC
	Miscarriage
< 38	11/33	33.3%	3/15	20.0%	0.35	0.57
≥ 38	2/12	16.7%	2/14	14.3%	0.87	0.52
All Ages	13/45	28.9%	5/29	17.2%	0.25	0.58
	Mosaic ≥20% to < 50% Mosaic		Mosaic ≥50% to ≤80% Abnormal		p-value	AUC
Age	Miscarriage				p-value	AUC
< 38	13/43	30.2%	1/5	20.0%	0.63	0.52
≥ 38	2/19	10.5%	2/7	28.6%	0.26	0.64
All Ages	15/62	24.2%	3/12	25.0%	0.95	0.50
	Mosaic ≥20% to < 60% Abnormal		Mosaic ≥60% to ≤80% Abnormal		p-value	AUC
Age	Miscarriage				p-value	AUC
< 38	14/48	29.2%	0/0	0.0%	–	–
≥ 38	2/20	10.0%	2/6	33.3%	0.16	0.66
All Ages	16/68	23.5%	2/6	33.3%	0.59	0.59
	Mosaic ≥20% to < 70% Abnormal		Mosaic ≥70% to ≤80% Abnormal		p-value	AUC
Age	Miscarriage				p-value	AUC
< 38	14/48	29.2%	0/0	0.0%	–	–
≥ 38	3/22	13.6%	1/4	25.0%	0.56	0.56
All Ages	17/70	24.3%	1/4	25.0%	0.97	0.50

AUC: area under the curve

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