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Table 1 Predictive ability of NGS trophectoderm biopsy for ongoing pregnancy based on proportion of abnormal cells in the specimen

From: Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos

  Euploid < 20% Abnormal Mosaic ≥20% to ≤80% Abnormal p-value AUC
Ongoing Pregnancy 661/1045 63.3% 56/143 39.2% < 0.0001 0.55
  Mosaic ≥20% to < 30% Abnormal Mosaic ≥30% to ≤80% Abnormal p-value AUC
Age Ongoing Pregnancy
< 38 12/27 44.4% 22/61 36.1% 0.46 0.54
≥ 38 1/8 12.5% 21/46 45.7% 0.08 0.59
All Ages 13/35 37.1% 43/108 39.9% 0.78 0.51
  Mosaic ≥20% to < 40% Abnormal Mosaic ≥40% to ≤80% Abnormal p-value AUC
Age Ongoing Pregnancy
< 38 22/61 36.1% 12/27 44.4% 0.46 0.54
≥ 38 10/25 40.0% 12/29 41.4% 0.92 0.51
All Ages 32/87 36.8% 24/56 42.9% 0.47 0.53
  Mosaic ≥20% to < 50% Mosaic Mosaic ≥50% to ≤80% Abnormal p-value AUC
Age Ongoing Pregnancy
< 38 30/78 38.5% 4/10 40.0% 0.93 0.50
≥ 38 17/38 44.7% 5/16 31.3% 0.36 0.56
All Ages 47/117 40.2% 9/26 34.6% 0.60 0.52
  Mosaic ≥20% to < 60% Abnormal Mosaic ≥60% to ≤80% Abnormal p-value AUC
Age Ongoing Pregnancy
< 38 34/86 39.5% 0/2 0.0% 0.26 0.52
≥ 38 18/44 40.9% 4/10 40.0% 0.96 0.50
All Ages 52/131 39.7% 4/12 33.3% 0.67 0.51
  Mosaic ≥20% to < 70% Abnormal Mosaic ≥70% to ≤80% Abnormal p-value AUC
Age Ongoing Pregnancy
< 38 34/87 39.1% 0/1 0.0% 0.42 0.51
≥ 38 19/46 41.3% 3/8 37.5% 0.84 0.51
All Ages 53/134 39.6% 3/9 33.3% 0.71 0.51
  1. AUC: area under the curve