Table 1 Predictive ability of NGS trophectoderm biopsy for ongoing pregnancy based on proportion of abnormal cells in the specimen
|  | Euploid < 20% Abnormal | Mosaic ≥20% to ≤80% Abnormal | p-value | AUC | ||
Ongoing Pregnancy | 661/1045 | 63.3% | 56/143 | 39.2% | < 0.0001 | 0.55 |
|  | Mosaic ≥20% to < 30% Abnormal | Mosaic ≥30% to ≤80% Abnormal | p-value | AUC | ||
Age | Ongoing Pregnancy | |||||
< 38 | 12/27 | 44.4% | 22/61 | 36.1% | 0.46 | 0.54 |
≥ 38 | 1/8 | 12.5% | 21/46 | 45.7% | 0.08 | 0.59 |
All Ages | 13/35 | 37.1% | 43/108 | 39.9% | 0.78 | 0.51 |
|  | Mosaic ≥20% to < 40% Abnormal | Mosaic ≥40% to ≤80% Abnormal | p-value | AUC | ||
Age | Ongoing Pregnancy | |||||
< 38 | 22/61 | 36.1% | 12/27 | 44.4% | 0.46 | 0.54 |
≥ 38 | 10/25 | 40.0% | 12/29 | 41.4% | 0.92 | 0.51 |
All Ages | 32/87 | 36.8% | 24/56 | 42.9% | 0.47 | 0.53 |
|  | Mosaic ≥20% to < 50% Mosaic | Mosaic ≥50% to ≤80% Abnormal | p-value | AUC | ||
Age | Ongoing Pregnancy | |||||
< 38 | 30/78 | 38.5% | 4/10 | 40.0% | 0.93 | 0.50 |
≥ 38 | 17/38 | 44.7% | 5/16 | 31.3% | 0.36 | 0.56 |
All Ages | 47/117 | 40.2% | 9/26 | 34.6% | 0.60 | 0.52 |
|  | Mosaic ≥20% to < 60% Abnormal | Mosaic ≥60% to ≤80% Abnormal | p-value | AUC | ||
Age | Ongoing Pregnancy | |||||
< 38 | 34/86 | 39.5% | 0/2 | 0.0% | 0.26 | 0.52 |
≥ 38 | 18/44 | 40.9% | 4/10 | 40.0% | 0.96 | 0.50 |
All Ages | 52/131 | 39.7% | 4/12 | 33.3% | 0.67 | 0.51 |
|  | Mosaic ≥20% to < 70% Abnormal | Mosaic ≥70% to ≤80% Abnormal | p-value | AUC | ||
Age | Ongoing Pregnancy | |||||
< 38 | 34/87 | 39.1% | 0/1 | 0.0% | 0.42 | 0.51 |
≥ 38 | 19/46 | 41.3% | 3/8 | 37.5% | 0.84 | 0.51 |
All Ages | 53/134 | 39.6% | 3/9 | 33.3% | 0.71 | 0.51 |