Table 1 The key regulators and their targets identified in the integrated network in endometriosis
ID | Node degree | Fold change | Target |
|---|---|---|---|
FOXC1 | 117 | 7.26 | ZNF521, MKX, ENOX1, TENM4, CHN2, PLXDC2, ZFHX4, COLEC12, FAM19A2, ICAM5, DCN, DGKG, PTPN3, PDGFC, PBX3, EPHA3, C7orf10, NMNAT3, MDFI, SCG5, GPC6, FGF14, ADAMTSL3, F13A1, FIGN, SNAP25, BNC2, GPR1, ICA1, BOC, PLXNC1, NRK, VDR, OMG, CHL1, SYNDIG1, DRP2, EPHB2, SORCS2, RP4-794H19.2, SDK1, PLCB4, HS6ST3, NTM, FAM133A, HOXA11, NUGGC, SELP, TTC29, HOXA3, NKAIN3, SYTL2, HOXA11-AS, EN2, CNTN3, DNAJC15, GPC3, GALNTL6, LINC00922, CASZ1, COL11A1, RAB11FIP4, RAB3C, AMPD1, C9orf135, TWIST2, MAP3K19, C9orf171, FRMD5, GRM8, GJB2, MECOM, ETV1, ALCAM, DOCK2, REV3L, EYA4, CACNA1D, PLXNA4, GRB7, SCN9A, PDE7B, PAX2, DLGAP1, PCDHA4, KPNA2, KIRREL3, CCDC19, SLC14A2, KLHL13, COL28A1, MAOA, MARCH1, CACNA1I, NEBL, SGCD, MAFB, LHFP, DSCAML1, ADAMTS9, POU6F2, PHLPP1, EYA2, ERBB4PCLO, OPCML, SESTD1, MAFF, MPZL2, SOX30, PLCZ1, RP11-536O18.2, RGS6, GRIN2A, CYTIP, ITPR1 |
FOXO1 | 64 | −3.56 | HAND2-AS1, EFNA1, GRB7, RASD1, EN2, ICA1, SESTD1, CNKSR2, RP11-383H13.1, VSIG2, CP, RP11-792D21.2, MRC1, PDGFC, BARX2, KCNH1, NKAIN3, HS6ST3, CHST9, WDFY4, HOXC4, PPP1R9A, NUAK1, PTPRR, LHFPL3, CR1, SHROOM3, PLCB4, RGS6, HOXC8, TMPRSS2, LINGO2, AOAH, COLEC12, MASP1, MAP3K5, MLIP, SPTLC3, TENM4, SLC2A1-AS1, PLXNC1, ZFHX4, SLC6A7, RALGAPA2, SORCS1, EPHB2, DNAJC6, HOXC6, MAFF, NMNAT3, NALCN, SMPX, SCN9A, ST8SIA4, CAPN8, TTYH2, NBL1, CD83, GALNT16, NTM, COL24A1, ST6GALNAC5, CPNE5, FGF10 |
miR-182-5p | 57 | −5.34 | RAB40B, SLC1A2, SCN1, APHYHIPL, FAT3, SLC2A8, FOXO1, CEBPA, PDE7B, RPH3A, ESRRG, CALCR, RHPN2, TP53INP2, SLITRK4, PTGER3, FN1, DENND2C, EPHA3, ZNF831, PIK3R1, SLC9A2, TCF19, SCN9A, GRIA1, FUT9, LDB3, PRRG3, PRDM16, SPRY3, ADRA2C, THBS2, SLC22A5, LIPG, FST, BNC2, ADAMTS18, GDNF, MPP1, FAM78A, KIAA1210, TMEM86A, RNF183, F13A1, ERBB4, NUAK1, IRF6, SEMA5A, LPPR4, AP1S3, MYO5B, KIAA1244, TPD52, GRHL2, CXADR, CELSR1, KIAA1324 |
miR-106a-5p | 49 | −3.72 | VASH2, OSM, MYCN, JAZF1, ETV1, BCL11B, TP73, ITGB8, SV2B, CD274, ANKRD33B, GRHL2, DENND5B, CYP26B1, LIF, PKIA, ERBB3, RASL11B, RORC, VEGFA, NR4A2, SHANK2, PARD6B, BHLHE41, GPC6, RASD1, PDE3B, HEG1, RUNX1, SULF1, MYO5B, TTC9, CNGB3, ZFPM2, BNC2, SLC46A3, PBX3, EXPH5, ADAMTSL2, PCYT1B, APCDD1, FAM129A, SEMA5A, FAIM2, MTF1, KIF5A, NBL1, PTPN3, NRP2 |
CEBPA | 49 | 5.73 | VASH2, OSM, MYCN, JAZF1, ETV1, BCL11B, TP73, ITGB8, SV2B, CD274, ANKRD33B, GRHL2, DENND5B, CYP26B1, LIF, PKIA, ERBB3, RASL11B, RORC, VEGFA, NR4A2, SHANK2, PARD6B, BHLHE41, GPC6, RASD1, PDE3B, HEG1, RUNX1, SULF1, MYO5B, TTC9, CNGB3, ZFPM2, BNC2, SLC46A3, PBX3, EXPH5, ADAMTSL2, PCYT1B, APCDD1, FAM129A, SEMA5A, FAIM2, MTF1, KIF5A, NBL1, PTPN3, NRP2 |
GATA1 | 41 | 7.62 | miR-202-3p, ATP10B, MATN3, PAPPA2, RAB31, PDE10A, FRMD5, ABCA6, PRR5L, TSPAN2, SLC8A3, SYNDIG1L, MDGA2, ENOX1, FOXC1, FGF14, CLIC6, RASGRF2, ANTXR1, ZNF469, PCYT1B, MAPK4, ENAM, NRP2, SYNPO, DRP2, CHN2, PDE7B, ZNF521, PPP2R2B, ITGA8, NTM, MKX, SLC14A2, GALNT5, COL8A1, BDNF, ADAMTSL2, DPYSL3, THSD7B, GPC6 |
miR-20b-5p | 40 | −4.16 | TP73, LIF, CYP26B1, RASL11B, GRHL2, SV2B, RASD1, CD274, DENND5B, VEGFA, HEG1, BCL11B, PARD6B, PKIA, MYO5B, RUNX1, GPC6, BHLHE41, PDE3B, SULF1, SHANK2, TTC9, EXPH5, NR4A2, SLC46A3, ZFPM2, BNC2, PCYT1B, ADAMTSL2, NBL1, PBX3, APCDD1, FAM129A, FAIM2, KIF5A, MTF1, PTPN3, NRP2, SEMA5A, CNGB3 |
miR-200b-3p | 37 | −16.72 | PLXNA4, CASR, ELK4, PARD3B, DCDC2, DENND5B, PARD6B, PKIA, KRT80, HOXA5, KLHL14, SGCE, NOG, PTCH1, GATA2, ST6GALNAC5, PRDM16, BNC2, SLC6A1, TP73, SCN3B, ANK3, HOOK1, PAG1, PVRL4, BAG5, GLIS2, JAZF1, DDIT4L, CNTFR, CHN2, CASZ1, NRP2, KIAA1456, OCLN, CECR2, PAK6 |
FOXL1 | 37 | 20.45 | miR-34c-5p, miR-34b-3p, miR-34b-5p, miR-133b, PDE3A, SV2B, PRDM16, HOXD10, ZFHX4, PLXNC1, MSRB3, ZNF521, SEMA5A, HOXD11, ST18, SCN9A, MCF2, ENOX1, NTF3, FOXO1, OPCML, EPB41L4B, C7orf10, PPL, KLHL13, CASZ1, MME, POSTN, RUNX1, COL24A1, VEGFA, GPC6, ANKRD33B, HPSE2, GRIA3, NRXN1, PLCB1 |
miR-363-3p | 36 | −2.92 | EN2, SLC12A5, NRK, BCL11B, SESTD1, PRKAR2B, DACT1, PTPRO, RHPN2, HEG1, BTG2, CACNA1H, B3GALT2, PPP1R9A, ZNF469, PRDM16, KLF2, HAND2, ZFHX4, ESRP1, WWC1, GRAMD1B, SLC6A1, MPP1, ZFPM2, GATA6, ADAMTSL3, TTC9, ADAMTS9, PDE10A, PCYT1B, MSRB3, HOXC8, HOXC4, MTF1, KCNH1 |
miR-200c-3p | 36 | −27.15 | PPP1R12B, CASR, FAT3, STX1A, DCDC2, VEGFA, PLXNA4, VASH2, PARD3B, JAZF1, PKIA, KRT80, DENND5B, RIMKLB, HOXA5, KIAA1456, SGCE, SLC6A1, PAK6, PRDM16, SCN3B, ST6GALNAC5, BNC2, HOOK1, ELK4, EFNA1, CASZ1, GLIS2, DDIT4L, PVRL4, PAG1, NRP2, CHN2, CECR2, PARD6B, OCLN |
miR-30d-5p | 29 | −3.93 | CHL1, MFSD6, CLCF1, PLS1, COL9A3, BNC2, NRXN3, ME1, EPHB2, NUAK1, PAG1, NRP2, RGS6, HOXB8, GDNF, CORO2A, EPB41L4B, RASD1, PPP1R9A, GCNT2, HELZ, ATP2B2, CECR2, GPT2, IP6K3, SCARA5, DLG5, RNF165, FAM83F |
miR-133b | 19 | 9.16 | BTBD3, FOXC1, ENPEP, JUP, ELF3, PTH1R, PRDM16, GPM6A, CTGF, BICC1, HOXD1, HOXA9, LHFP, CELF4, LTBP1, GDNF, PTPRZ1, LRRC2, ANK2 |
miR-449b-5p | 14 | −114.1 | PKIA, FUT9, GAS1, NR4A2, RAB11FIP4, CSF1R, KIAA1045, ZDHHC23, GABRA3, SIDT1, ANK3, SPRY3, TPD52, PCLO |
miR-449a | 13 | −70.83 | CSF1R, ANK3, ZDHHC23, FUT9, SDK2, GNAO1, GABRA3, TPD52, SBK1, NR4A2, SPRY3, PCLO, DPYSL4 |
miR-196b-5p | 13 | −13.72 | HMGA1, OPCML, COL1A1, NRK, IGDCC4, RGS6, ELK4, PARD6B, HOOK1, BNC2, PBX3, HOXA9, HOXC8 |
SOX9 | 13 | −12.89 | MELK, DCDC2, NTN1, DPP6, UNC93A, FOSL1, ASIC2, LINC00669, NPAS3, BRIP1, DMBT1, EN2, C20orf26 |
HNF4A | 12 | −9.63 | miR-20b-5p, miR-363-3p, miR-106a-5p, miR-196b-5p, miR-182-5p, miR-224-5p, miR-183-5p, miR-200a-3p, miR-708-5p, miR-200b-3p, miR-216a-5p, miR-449a |
miR-34c-5p | 11 | −15.91 | SPRY3, KIAA1045, GABRA3, ANK3, STX1A, CSF1R, PARD6B, PCLO, RAP1GAP, TPD52 |
miR-200a-3p | 9 | −35.83 | SCD5, PLXNA4, CYP26B1, PLXDC1, PAPPA, OSBPL6, MN1, RHPN2, GATA6 |
miR-141-3p | 9 | −56.69 | PLXNA4, PLXDC1, SCD5, PAPPA, MN1, CYP26B1, GATA6, OSBPL6, RHPN2 |
miR-183-5p | 7 | −5.72 | EZR, RAB11FIP4, KIAA0101, SLC1A2, MAL2, SLAIN1, SPRY3 |
E2F1 | 4 | −3.74 | miR-449a, miR-449c-5p, miR-449b-5p, MELK |
FOXJ1 | 1 | −98.82 | miR-449a |
E2F2 | 1 | −3.56 | miR-196b-5p |