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Table 2 Mouse models to study TGFβ superfamily signaling in uterine function

From: TGFβ superfamily signaling and uterine decidualization

Mouse model Phenotype Reference
Tgfbr1 Amhr2-Cre cKO Disrupted myometrial formation with occurrence of artificial decidualization [29]
Tgfbr1 Pgr-Cre cKO Defective placentation, impaired recruitment of uNK cells, with occurrence of artificial decidualization [64]
Bmp2 Pgr-Cre cKO Infertility with loss of decidualization [41]
Bmp7 Pgr-Cre cKO Defective implantation with normal response to artificial decidualization stimuli [52]
Fst Pgr-Cre cKO Defective uterine receptivity and decidualization [54]
Nodal Pgr-Cre cKO Malformation of decidua basalis with fetal loss and preterm birth [56]
Acvr1 Pgr-Cre cKO Infertility with defective implantation and decidualization [59]
Acvr1b Pgr-Cre cKO Defective placental development but normal occurrence of implantation and decidualization [66]
Bmpr1a Pgr-Cre cKO Impaired implantation and decidualization [60]
Bmpr1a Amhr2-Cre cKO Subfertility with prolonged diestrous phase and occurrence of decidualization [61]
Bmpr1b KO Infertility, impaired expansion of cumulus cells of oocytes and uterine gland formation [62]
Bmpr2 Pgr-Cre cKO Infertility, defective decidual vascularization and decidualization [63]
Smad3 KO Impaired artificial decidualization [67]
Smad1/5/4 Amhr2-Cre cKO Defective oviductal and myometrial development, impaired implantation and decidualization [69]