TGFβ superfamily signaling and uterine decidualization

Table 2 Mouse models to study TGFβ superfamily signaling in uterine function

Mouse model	Phenotype	Reference
Tgfbr1 Amhr2-Cre cKO	Disrupted myometrial formation with occurrence of artificial decidualization	[29]
Tgfbr1 Pgr-Cre cKO	Defective placentation, impaired recruitment of uNK cells, with occurrence of artificial decidualization	[64]
Bmp2 Pgr-Cre cKO	Infertility with loss of decidualization	[41]
Bmp7 Pgr-Cre cKO	Defective implantation with normal response to artificial decidualization stimuli	[52]
Fst Pgr-Cre cKO	Defective uterine receptivity and decidualization	[54]
Nodal Pgr-Cre cKO	Malformation of decidua basalis with fetal loss and preterm birth	[56]
Acvr1 Pgr-Cre cKO	Infertility with defective implantation and decidualization	[59]
Acvr1b Pgr-Cre cKO	Defective placental development but normal occurrence of implantation and decidualization	[66]
Bmpr1a Pgr-Cre cKO	Impaired implantation and decidualization	[60]
Bmpr1a Amhr2-Cre cKO	Subfertility with prolonged diestrous phase and occurrence of decidualization	[61]
Bmpr1b KO	Infertility, impaired expansion of cumulus cells of oocytes and uterine gland formation	[62]
Bmpr2 Pgr-Cre cKO	Infertility, defective decidual vascularization and decidualization	[63]
Smad3 KO	Impaired artificial decidualization	[67]
Smad1/5/4 Amhr2-Cre cKO	Defective oviductal and myometrial development, impaired implantation and decidualization	[69]

ISSN: 1477-7827