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Table 1 Major roles of TGFβ superfamily in reproduction and development

From: TGFβ superfamily signaling and uterine decidualization

Reproductive event Main signaling component Reference
Folliculogenesis TGFβs, GDF9, BMP2, BMP4, BMP7  
Oocyte maturation BMP15, activin, inhibin, AMH [1, 4,5,6,7,8,9,10,11,12,13,14,15,16, 61, 105]
Ovulation BMPR1A, BMPR1B, SMAD2/3, SMAD4  
Maternal-embryo interactions TGFβs, BMP7, BMPR1B, BMPR2, SMAD1, SMAD6 [17,18,19]
Implantation TGFβ1, ACVR1, BMPR1A, TGFBR1, BMP7 [52, 59, 64, 106]
Decidualization BMP2, SMAD1/5/4, SMAD2/3, ACVR1, BMPR1A, BMPR2, FST, LEFTY [41, 54, 57,58,59,60, 63, 67, 69]
Embryonic development TGFβs, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8, INHBA, INHBB, GDF1, LEFTY, NODAL, AMH, SMAD1, SMAD2, SMAD4, SMAD5, SMAD6, SMAD7, ACVRL1, ACVR1, BMPR1A, ACVR1B, TGFBR1, BMPR1B, TGFBR2, ACVR2/2B, AMHR2, BMPR2 [20,21,22,23,24,25, 107, 108]
Reproductive tract development TGFBR1, AMH, AMHR2, ACVR1, BMPR1A, SMAD1/5/8, SMAD4 [29, 30, 109, 110]