Table 6 Morphokinetic characteristics of human cryopreserved embryos after thawing/warming in dataset 2. P-values are based on a clustered logrank test. Hazard ratios and 95% CIs are based on simple random effects Cox proportional hazards regression models, modeling mother as random effect
N cells at freezing mean±SD | Mitosis resumption N (%) | Hours to mitosis resumption Median | HR | 95% CI | P | Compaction N (%) | Hours to Compaction Median | HR | 95% CI | P | |
|---|---|---|---|---|---|---|---|---|---|---|---|
All embryos | 8.1±1.5 | 67 (74) | 9.9 | 42 (47) | NA | ||||||
Type of freezing | |||||||||||
Slow freezing | 8.0±1.6 | 22 (63) | 13.1 | 0.49 | 0.27 to 0.88 | 0.0185 | 8 (23) | NA | 0.22 | 0.10 to 0.51 | 0.0001 |
Vitrification | 8.1±1.5 | 45 (82) | 7.6 | 34 (62) | 18.1 | ||||||
Intact | |||||||||||
No | 8.1±1.7 | 21 (66) | 14.6 | 1.86 | 1.04 to 3.31 | 0.0335 | 11 (34) | NA | 2.28 | 1.03 to 5.05 | 0.0638 |
Yes | 8.1±1.4 | 46 (79) | 7.6 | 31 (53) | 20.1 | ||||||
Implanted | |||||||||||
No | 8.2±1.7 | 47 (69) | 11.5 | nc | nc | 0.2062 | 27 (40) | NA | nc | nc | 0.1345 |
Yes | 7.6±0.6 | 13 (93) | 7.2 | 9 (64) | 17.6 | ||||||