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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Effects of melatonin administration on embryo implantation and offspring growth in mice under different schedules of photoperiodic exposure

Fig. 4

Effects of melatonin on the protein expression of MT1, MT2 and p53 on Day 4.5 in uterine tissue. (a1) On Day 4.5, MT1 and MT2 receptor expression in the uterus was significantly higher in melatonin (10−4 M)-treated samples than in control samples (MT1: 27.8 ± 3.23% vs. control 10.7 ± 5.38% and MT2: 50.5 ± 3.41% vs. control 26.6 ± 5.29%; P < 0.05), and MT2 expression was higher than MT1 expression. (b1) Uterine p53 expression significantly increased in melatonin-treated group (38.3 ± 3.69% vs. control 26.4 ± 2.65%; P < 0.05). (c1) The relative protein expression level of LIF. There was no significant difference between the melatonin and control group (26.9 ± 6.50% vs. control 26.3 ± 4.73%; P > 0.05). (a2, b2 & c2) Western blotting results of uterine MT1, MT2, p53 and LIF protein expression. Different superscript letters indicate statistically significant differences (P < 0.05). Data are expressed as the means ± SEM (N = 8). Different superscript letters indicate statistically significant differences (P < 0.05)

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