Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

Table 4 Variations of selected metabolic parameters between follow-up and baseline and compared between PCOSr and controls girls

Conditions	Metabolic parameter	Calculated parameter	Controls (n = 8)	PCOSr (n = 8)	p
Duration of follow-up (years)			5.4 (5.3–6.0)	5.6 (4.6–6.6)	1.000
Anthropometric measures	Adiposity	BMI Z-score	0.81 (−0.19–1.32)	−0.08 (−0.43–0.17)	0.105
Anthropometric measures		WHtR Z-score	0.50 (−0.18–1.07)	−0.43 (−0.93–0.21)	0.050
OGTT	Insulin sensitivity	ISI_Matsuda	−7.7 (−12.2 – −2.2)^a	−0.7 (−3.9–2.5)	0.050
	β-cell function	DI_OGTT	−4.0 (−8.6 – −1.4)^a	0.2 (−1.6–3.4)	0.010*
	NEFA suppressibility	Log_n-linear slope	0.023 (0.016–0.027)^a	−0.006 (−0.014 – −0.001)^a	0.001
	NEFA suppressibility	T50_NEFA (min)	18.2 (3.4–33.5)^a	10.5 (−0.6–17.4)	0.161
FSivGTT	Insulin sensitivity	IS_FSivGTT	−7.3 (−11.6 – −4.6)^a	−0.5 (−2.0–0.3)	0.001*
	Insulin secretion	AIRg	274 (89–506)^a	190 (56–328)^a	0.442
	β-cell function	DI_FSivGTT	−689 (−1693 – −333)^a	614 (−151–1233)	0.003*
	NEFA suppressibility	Log_n-linear slope	0.015 (0.003–0.033)	−0.001 (−0.067–0.012)	0.083
		T50_NEFA (min)	9.6 (3.0–13.9)^a	−1.3 (−6.0–6.5)	0.065

Values are expressed as median (25th–75th percentiles) and compared with Mann-Whitney test
^aSignificant change between baseline and follow-up: p < 0.05 analyzed with paired Wilcoxon test
*p < 0.05 after correction for the difference in WHtR Z-score between follow-up and baseline
AIRg Acute insulin response to glucose, FSivGTT Frequent sampling intra-venous glucose tolerance test, DI Glucose disposition index, DI _OGTT ISI_Matsuda × CIR30, DI _FSivGTT IS_FSivGTT × AIRg, IS _FSivGTT Insulin sensitivity determined during the FSivGTT, ISI Insulin sensitivity index, Log _n -linear slope Slope of Ln of NEFA concentrations (between time 0 to 20 min for the FSivGTT), NEFA Non-esterified fatty acid, OGTT Oral glucose tolerance test, and T50 _NEFA Time to suppress 50% of NEFA baseline levels and WHtR Ratio of waist circumference (cm) to height (cm)

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