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Table 4 Variations of selected metabolic parameters between follow-up and baseline and compared between PCOSr and controls girls

From: Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

Conditions Metabolic parameter Calculated parameter Controls (n = 8) PCOSr (n = 8) p
Duration of follow-up (years) 5.4 (5.3–6.0) 5.6 (4.6–6.6) 1.000
Anthropometric measures Adiposity BMI Z-score 0.81 (−0.19–1.32) −0.08 (−0.43–0.17) 0.105
  WHtR Z-score 0.50 (−0.18–1.07) −0.43 (−0.93–0.21) 0.050
OGTT Insulin sensitivity ISIMatsuda −7.7 (−12.2 – −2.2)a −0.7 (−3.9–2.5) 0.050
β-cell function DIOGTT −4.0 (−8.6 – −1.4)a 0.2 (−1.6–3.4) 0.010*
NEFA suppressibility Logn-linear slope 0.023 (0.016–0.027)a −0.006 (−0.014 – −0.001)a 0.001
T50NEFA (min) 18.2 (3.4–33.5)a 10.5 (−0.6–17.4) 0.161
FSivGTT Insulin sensitivity ISFSivGTT −7.3 (−11.6 – −4.6)a −0.5 (−2.0–0.3) 0.001*
Insulin secretion AIRg 274 (89–506)a 190 (56–328)a 0.442
β-cell function DIFSivGTT −689 (−1693 – −333)a 614 (−151–1233) 0.003*
NEFA suppressibility Logn-linear slope 0.015 (0.003–0.033) −0.001 (−0.067–0.012) 0.083
  T50NEFA (min) 9.6 (3.0–13.9)a −1.3 (−6.0–6.5) 0.065
  1. Values are expressed as median (25th–75th percentiles) and compared with Mann-Whitney test
  2. aSignificant change between baseline and follow-up: p < 0.05 analyzed with paired Wilcoxon test
  3. *p < 0.05 after correction for the difference in WHtR Z-score between follow-up and baseline
  4. AIRg Acute insulin response to glucose, FSivGTT Frequent sampling intra-venous glucose tolerance test, DI Glucose disposition index, DI OGTT ISIMatsuda × CIR30, DI FSivGTT ISFSivGTT × AIRg, IS FSivGTT Insulin sensitivity determined during the FSivGTT, ISI Insulin sensitivity index, Log n -linear slope Slope of Ln of NEFA concentrations (between time 0 to 20 min for the FSivGTT), NEFA Non-esterified fatty acid, OGTT Oral glucose tolerance test, and T50 NEFA Time to suppress 50% of NEFA baseline levels and WHtR Ratio of waist circumference (cm) to height (cm)