Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

Table 3 Calculated metabolic parameters at 5-year follow-up, based on OGTT and FSivGTT measures

Conditions	Metabolic parameter	Calculated parameter	Controls (n = 8)	PCOSr (n = 8)	p
OGTT	Insulin sensitivity	ISI_Matsuda	3.6 (2.4–7.3)	3.8 (2.6–6.0)	0.798
	Insulin secretion	CIR30	1.1 (0.6–1.3)	1.2 (0.8–1.7)	0.574
	β-cell function	DI_OGTT	2.7 (2.3–4.7)	4.4 (4.1–6.1)	0.195
	NEFA suppressibility	Log_n-linear slope	−0.028 (−0.030 – −0.018)	−0.040 (−0.044 – −0.036)	<0.001
		Log_n-linear slope / AUC_insulin	−0.58 (−1.02 – −0.23)	−0.81 (−1.29 – −0.51)	0.195
		T50_NEFA (min)	40.6 (28.3–48.5)	34.1 (24.4–47.0)	0.645
FSivGTT	Insulin sensitivity	IS_FSivGTT	3.4 (1.8–3.6)	3.2 (2.2–5.3)	0.878
	Insulin secretion	AIRg	790 (343–813)	496 (361–997)	0.959
	β-cell function	DI_FSivGTT	1380 (1122–2563)	1926 (1376–2264)	0.442
	NEFA suppressibility	Log_n-linear slope	−0.032 (−0.040 – −0.024)	−0.032 (−0.088 – −0.018)	0.878
		Log_n-linear slope / AUC_insulin	−4.33 (−6.42 – −3.14)	−3.33 (−7.64 – −2.67)	0.505
		T50_NEFA (min)	20.8 (16.2–26.9)	18.1 (16.1–23.9)	0.574

Values are expressed as median (25th–75th percentiles) and compared with Mann-Whitney test
AIRg Acute insulin response to glucose, AUC Area under the curve, CIR30 Corrected insulin response at 30 min, FSivGTT Frequent sampling intra-venous glucose tolerance test, DI Glucose disposition index, DI _OGTT ISI_Matsuda × CIR30, DI _FSivGTT IS_FSivGTT × AIRg, IS _FSivGTT Insulin sensitivity determined during the FSivGTT, ISI Insulin sensitivity index, Log _n -linear slope Slope of Ln of NEFA concentrations (between time 0 to 20 min for the FSivGTT), Log _n -linear slope /AUC _Insulin Ratio of the Slope of Ln of NEFA concentrations to the area under the insulin curve ×1000 (between time 0 to 20 min for the FSivGTT), NEFA Non-esterified fatty acid, OGTT Oral glucose tolerance test, and T50 _NEFA Time to suppress 50% of NEFA baseline levels

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