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Table 3 Calculated metabolic parameters at 5-year follow-up, based on OGTT and FSivGTT measures

From: Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

Conditions Metabolic parameter Calculated parameter Controls (n = 8) PCOSr (n = 8) p
OGTT Insulin sensitivity ISIMatsuda 3.6 (2.4–7.3) 3.8 (2.6–6.0) 0.798
Insulin secretion CIR30 1.1 (0.6–1.3) 1.2 (0.8–1.7) 0.574
β-cell function DIOGTT 2.7 (2.3–4.7) 4.4 (4.1–6.1) 0.195
NEFA suppressibility Logn-linear slope −0.028 (−0.030 – −0.018) −0.040 (−0.044 – −0.036) <0.001
  Logn-linear slope / AUCinsulin −0.58 (−1.02 – −0.23) −0.81 (−1.29 – −0.51) 0.195
  T50NEFA (min) 40.6 (28.3–48.5) 34.1 (24.4–47.0) 0.645
FSivGTT Insulin sensitivity ISFSivGTT 3.4 (1.8–3.6) 3.2 (2.2–5.3) 0.878
Insulin secretion AIRg 790 (343–813) 496 (361–997) 0.959
β-cell function DIFSivGTT 1380 (1122–2563) 1926 (1376–2264) 0.442
NEFA suppressibility Logn-linear slope −0.032 (−0.040 – −0.024) −0.032 (−0.088 – −0.018) 0.878
  Logn-linear slope / AUCinsulin −4.33 (−6.42 – −3.14) −3.33 (−7.64 – −2.67) 0.505
  T50NEFA (min) 20.8 (16.2–26.9) 18.1 (16.1–23.9) 0.574
  1. Values are expressed as median (25th–75th percentiles) and compared with Mann-Whitney test
  2. AIRg Acute insulin response to glucose, AUC Area under the curve, CIR30 Corrected insulin response at 30 min, FSivGTT Frequent sampling intra-venous glucose tolerance test, DI Glucose disposition index, DI OGTT ISIMatsuda × CIR30, DI FSivGTT ISFSivGTT × AIRg, IS FSivGTT Insulin sensitivity determined during the FSivGTT, ISI Insulin sensitivity index, Log n -linear slope Slope of Ln of NEFA concentrations (between time 0 to 20 min for the FSivGTT), Log n -linear slope /AUC Insulin Ratio of the Slope of Ln of NEFA concentrations to the area under the insulin curve ×1000 (between time 0 to 20 min for the FSivGTT), NEFA Non-esterified fatty acid, OGTT Oral glucose tolerance test, and T50 NEFA Time to suppress 50% of NEFA baseline levels