Towards a better understanding of preimplantation genetic screening for aneuploidy: insights from a virtual trial for women under the age of 40 when transferring embryos one at a time

Table 4 Cost-effectiveness summary: genetic testing versus not testing for 1000 virtual women

Group	Outcome	n	FET cost (£)	PGS cost (£)	Total cycle cost (£)	ICER (£)	More effective (n)			No effect (n)			Less effective (n)
Group	Outcome	n	FET cost (£)	PGS cost (£)	Total cycle cost (£)	ICER (£)	Less expensive	Same expense	More expensive	Less expensive	Same expense	More expensive	Less expensive	Same expense	More expensive
No testing	Miscarriage	56	1550	-	7,547,400	-	-	-	-	-	-	-	-	-	-
	Live birth	648				-	-	-	-	-	-	-	-	-	-
PGS1	Miscarriage	37	1550	2965	9,086,650	81,013	9	0	10	144	114^a	722	0	0	1^b
	Live birth	633				N/A	0	0	0	152	114^a	719	1^c	0	14^c
	Time						145	0	269	8	114^a	457	0	0	7^c
PGS2	Miscarriage	46	1550	2965	9,606,150	205,875	5	0	5	80	114^a	795	0	0	1^b
	Live birth	648				N/A	0	0	0	85	114^a	801	0	0	0
	Time						77	0	176	8	114^a	604	0	0	21^b,c,d
PGS3	Miscarriage	0	1550	2965	7,955,150	7281	38	0	16	332	114^a	500	0	0	0
	Live birth	652				101,938	4	0	0	366	114^a	516	0	0	0
	Time						359	0	235	9	114^a	281	2^e	0	0

^aWomen with no embryos suitable for transfer or testing. ^bPGS was less effective for miscarriage in one cycle due a live birth event associated with an embryo with a false positive test result, which occurred in an earlier transfer attempt when not acting on the test results, than a miscarriage associated with a later transfer attempt of embryos with euploid results following genetic testing. ^cPGS less effective due to exclusion of false positives. ^dPGS less effective due to the transfer order and fewer warming failures. ^ePGS less effective for time due to a live birth event in the fresh transfer of an embryo following testing that did not survive warming in a later transfer attempt without testing

ISSN: 1477-7827