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Table 4 Cost-effectiveness summary: genetic testing versus not testing for 1000 virtual women

From: Towards a better understanding of preimplantation genetic screening for aneuploidy: insights from a virtual trial for women under the age of 40 when transferring embryos one at a time

Group Outcome n FET cost (£) PGS cost (£) Total cycle cost (£) ICER (£) More effective (n) No effect (n) Less effective (n)
Less expensive Same expense More expensive Less expensive Same expense More expensive Less expensive Same expense More expensive
No testing Miscarriage 56 1550 - 7,547,400 - - - - - - - - - -
  Live birth 648     - - - - - - - - - -
PGS1 Miscarriage 37 1550 2965 9,086,650 81,013 9 0 10 144 114a 722 0 0 1b
  Live birth 633     N/A 0 0 0 152 114a 719 1c 0 14c
  Time       145 0 269 8 114a 457 0 0 7c
PGS2 Miscarriage 46 1550 2965 9,606,150 205,875 5 0 5 80 114a 795 0 0 1b
  Live birth 648     N/A 0 0 0 85 114a 801 0 0 0
  Time       77 0 176 8 114a 604 0 0 21b,c,d
PGS3 Miscarriage 0 1550 2965 7,955,150 7281 38 0 16 332 114a 500 0 0 0
  Live birth 652     101,938 4 0 0 366 114a 516 0 0 0
  Time       359 0 235 9 114a 281 2e 0 0
  1. aWomen with no embryos suitable for transfer or testing. bPGS was less effective for miscarriage in one cycle due a live birth event associated with an embryo with a false positive test result, which occurred in an earlier transfer attempt when not acting on the test results, than a miscarriage associated with a later transfer attempt of embryos with euploid results following genetic testing. cPGS less effective due to exclusion of false positives. dPGS less effective due to the transfer order and fewer warming failures. ePGS less effective for time due to a live birth event in the fresh transfer of an embryo following testing that did not survive warming in a later transfer attempt without testing