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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Role of microRNAs in premature ovarian insufficiency

Fig. 2

Biosynthesis of miRNA and the machinery molecules associated with POI. MicroRNAs(miRNAs) are transcribed into primary miRNA (pri-miRNA) by RNA polymerase II and are cleaved by RNase III enzyme Drosha complex to generate the precursor miRNAs (pre-miRNAs) in the nucleus. Pre-miRNAs are transported to the cytoplasm by XPO5. Pre-miRNAs are further processed by RNase III enzyme, Dicer complex, to form mature miRNAs,which then are incorporated into the RNA-induced silencing complex (RISC), resulting in mRNA degradation or translational repression of target genes. XPO5 and Dicer were reported to be associated with POI and are marked by red arrows

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