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Table 4 Increasing the accuracy of genetic diagnosis following selection of additional donors

From: Improving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype

 

First chosen donor

Total no. of additional tested donors

Newly selected donor

Subject No.

No. of informative markers

Misdiagnosis risk

No. of informative markers

Misdiagnosis risk

 #6

4

0.05% in female offspring

3

5

0.10%

 #7

1

15% in female offspring

4

5

0.10%

 #12

1

15%

4

3

1.56%

 #13

1

15%

5

3

1.56%

 #14

3

0.34%

8

5

0.10%

 #15

2

2.25%

2

6

0.02%

 #16

3

0.34%

4

4

0.39%

 #17

4

0.0506%

4

9

0.0004%

Average ± SEM

2.38 ± 1.30

6.00% ±7.48

4.25 ± 1.75

5.00 ± 1.93

0.48% ±0.68