Table 3 Animal models of miscellaneous interventions
Author, year [reference] | Animal | N | Intervention | Variables studied | Results |
|---|---|---|---|---|---|
Intervention period: Embryonic | |||||
Risma et al. 1997 [37] | Mouse | 20 | transgenic (bLHβ-CTP) | Sexual hormones Gonadotropin Ovary morphology | ↑ E2, ↑ T ↑ LH ↑ cystic follicles |
Shi et al. 2009 [38] | Rat | 18 | transgenic (JCR:LA-cp) | Sexual hormones Ovary morphology | ↑ T = E2 ↑ cystic follicles ↑ atretic follicles |
Devin et al. 2007 [39] | Mouse | 39 | transgenic (PAI-1) | Sexual hormones Ovary morphology | ↑ T ↑ cystic follicles ↓ CL |
Intervention period: Puberty | |||||
Kafali et al. 2004 [40] | Rat | 34 | Letrozole 21 days | Sexual hormones Gonadotropin Ovary morphology | ↑ T, ↓E2, ↑ LH, ↑ cystic follicles ↓ CL |
Kang et al. 2015 [47] | Sprague–Dawley Rat | light exposition During 112 days | Sexual hormones Ovary morphology | ↑ T ↑ cystic follicles ↑ atretic follicles | |
Intervention period: Adult | |||||
Bernuci et al. 2008 [42] | Rat | 17 | Chronic cold stress + LC lesion 60 days | Sexual hormones Ovary morphology | ↑ T ↑ E2, = LH = FSH ↑ cystic follicles ↓ ovulation |
Park and Choi, 2012 [43] | Mouse | 15 | D-galactose 45 days | Sexual hormone Ovarian morphology | ↑ T ↑ cystic follicles |
Ota, et al. 1987 [44] | Rat | 33 | hCG 80 days | Sexual hormones Gonadotropin Ovary morphology | = T ↑ E2 = LH = FSH ↑ cystic follicles |
Baldissera, et al. 1991 [41] | Rat | 15 | Light exposure 74 days | Ovary morphology Gonadotropin | ↑ cystic follicles ↓ CL = LH = FSH |
Lagace &Nachtigal, 2003 [45] | Rat | 22 | Valproic acid 30 days | Sexual hormones Ovary morphology | = E2 = T ↑ replace cysts by cystic follicles |
Radavelli- Bagatini et al. 2011 [46] | Mouse | 45 | Genetic | Sexual hormones Gonadotropin Ovary morphology | ↓ T ↑ E2 ↓ LH ↓ CL, ↑ replace cysts by cystic follicles, ↑ atretic follicles |
Li et al. 2016 [48] | Rat | 10 | Letrozole | Sexual hormones Gonadotropin Ovary morphology | ↑ T, ↓ E2 ↑ LH, ↑ FSH ↑ cystic follicles |