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Table 2 Studies using drugs with estrogenic effects

From: Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

Author, year [reference]

Animal

N

Intervention

Studied variables

Results

Intervention period: Postnatal and puberty

 Cruz et al. 2012 [29]

Sprague–Dawley rats

30

Estradiol valerate

Single dose

Sexual hormones

Gonadotropin

Ovary morphology

↑ E2 ↓ androstenedione = LH ↑ atretic follicles ↓ corpora lutea ↑ cystic follicles

 Schulster et al. 1984 [30]

Wistar rats (pubertal)

65

Estradiol valerate

Single dose

Sexual hormones

Gonadotropin

Ovary morphology

↓ E2 ↓ LH ↑ cystic follicles

 Brawer et al. 1986 [31]

Wistar rats (pubertal)

50

Estradiol valerate

Single dose

Gonadotropin

Ovary morphology

↓ LH ↓ FSH ↑ cystic follicles ↑ atretic follicles No CL

 Fernández et al. 2010 [32]

Sprague–Dawley rats

30

Bisphenol A

10 days

Sex hormones

Ovary morphology

↑E2 ↑ T ↑ cystic follicles ↑ atretic follicles ↓ CL

 Marcondes et al. 2015 [27]

Wistar rats

10

Estradiol Benzoate

Single dose

Sexual hormones

Gonadotropin

Ovarian morphology

=T = LH = FSH ↑ cystic follicles No CL

Intervention Period: Adulthood

 Hemmings et al. 1983 [35]

Wistar rats

32

Estradiol valerate

Single dose

Sexual hormones

Gonadotropin

Ovary morphology

= T ↓ LH ↑ cystic follicles

 Quandt et al. 1993 [34]

Guinea pigs

32

Estradiol-17β

2 days

Sexual hormones

Ovary morphology

↑ E2 = androstenedione ↑ cystic follicles ↑ atretic follicles

 Zangeneh et al. 2011 [33]

Wistar rats

48

Estradiol valerate

Single dose

+ cold stress simultaneously

Sex hormones

Gonadotropin Ovary morphology

↑ E2 = LH = FSH ↑ cystic follicles

 McCarthy & Brawer, 1990 [36]

Wistar rats

58

E2 pellets 50 days

Sexual hormones

Gonadotropin

Ovary morphology

= E2 ↑ cystic follicles No CL

  1. T testosterone, E2 estradiol, LH luteinizing hormone, FSH follicle-stimulating hormone, CL corpus luteum; ↑: increase; ↓ decrease; = equal