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Table 3 Oocyte characteristics and ART outcomes in women receiving autologous versus donor vitrified oocytes

From: The Human Oocyte Preservation Experience (HOPE) Registry: evaluation of cryopreservation techniques and oocyte source on outcomes

 

Autologous oocyte use

Donor oocyte use

(n = 95)

p valuea

Oocyte age <35 years

(n = 24)

Oocyte age ≥35 years

(n = 26)

All ages

(n = 50)

Oocyte age (years), mean ± SD; range

30.5 ± 2.2; 25–34

37.3 ± 1.9; 35–43

33.9 ± 3.9; 25–43

26.0 ± 2.8; 21–31

< 0.01

Total number of cycles started

21

25

46

94

 

Total number of oocytes warmed

194

231

425

694

 

Oocytes warmed per cycle, mean ± SD

9.2 ± 4.1

9.2 ± 4.1

9.2 ± 4.1

7.4 ± 2.5

< 0.01

Oocyte survival rate,b mean ± SD

70.9% ± 21.4%

84.2% ± 20.5%

78.1% ± 21.7%

86.0% ± 19.4%

0.03

2PN oocytes, mean ± SD

5.1 ± 3.2

5.4 ± 3.7

5.2 ± 3.5

5.2 ± 1.8

0.99

Embryo transfers,c n (% of cycles)

19 (90.5)

21 (84.0)

40 (87.0)

91 (96.8)

0.06

 Transfers on Day 3,d n (% of transfers)

10 (52.6)

12 (57.1)

22 (55.0)

19 (20.9)

< 0.01

 Transfers on Day 5/6,d n (% of transfers)

8 (42.1)

9 (42.9)

17 (42.5)

68 (74.7)

< 0.01

Embryos transferred per cycle, mean ± SD

2.4 ± 0.9

3.0 ± 1.0

2.7 ± 1.0

2.1 ± 0.6

< 0.01

 Day 3 transfer,d mean ± SD

2.8 ± 1.0

3.3 ± 1.1

3.0 ± 1.1

2.7 ± 0.7

0.30

 Day 5/6 transfer,d mean ± SD

1.9 ± 0.4

2.6 ± 0.7

2.2 ± 0.7

2.0 ± 0.4

0.13

Embryo cryopreservations, n (% of cycles)

4 (19.0)

6 (24.0)

10 (21.7)

50 (53.2)

< 0.01

Embryos cryopreserved, mean ± SD

1.8 ± 1.0

3.5 ± 1.8

2.8 ± 1.7

2.3 ± 1.1

0.37

Implantation rate,e mean ± SD

19.3% ± 33.5%

11.5% ± 19.5%

15.2% ± 26.9%

50.4% ± 45.8%

< 0.01

 Day 3 transfers, mean ± SD

11.7% ± 19.3%

11.8% ± 18.3%

11.7% ± 18.3%

12.3% ± 22.1%

0.92

 Day 5/6 transfers, mean ± SD

31.3% ± 45.8%

11.1% ± 22.0%

20.6% ± 35.6%

61.0% ± 45.7%

< 0.01

Clinical pregnancies, n (% of transfers)

6 (31.6)

6 (28.6)

12 (30.0)

57 (62.6)

< 0.01

 Day 3 transfers,d n (% of transfers)

3 (30.0)

4 (33.3)

7 (31.8)

5 (26.3)

0.74

 Day 5/6 transfers,d n (% of transfers)

3 (37.5)

2 (22.2)

5 (29.4)

49 (72.1)

< 0.01

Live birth deliveries, n (% of cycles)f

5 (23.8)

3 (12.0)

8 (17.4)

49 (52.1)

< 0.01

Number of oocytes needed for a live birthg

38.8

77.0

53.1

9.3

< 0.01

Oocyte efficiency, number of live births (% of warmed/thawed oocytes)h

5 (2.6)

3 (1.3)

8 (1.9)

75 (10.8)

< 0.01

  1. 2PN two-pronuclear; ART assisted reproductive technology; ICSI intracytoplasmic sperm injection; SD standard deviation
  2. a p values for comparison between patients using autologous oocytes (all ages) versus patients using donor oocytes are from t-tests for comparison of means and from Fisher’s exact tests for comparisons of percentages
  3. b Percentage of oocytes warmed that underwent ICSI
  4. c Patients not undergoing embryo transfer had no oocytes to transfer (ie, they failed at a stage between oocyte warm/thaw and transfer)
  5. d Embryo transfer date minus oocyte warming date. Remaining embryo transfers for each group were performed on other days
  6. e Percentage of embryos transferred that successfully undergo implantation and develop fetal sacs with heartbeat
  7. f Percentage of cycles started resulting in live birth of one or more babies
  8. g Number of oocytes warmed divided by number of live births
  9. h Percentage of oocytes warmed resulting in a live birth
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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