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Table 5 Top 20 canonical pathways identified by IPA

From: Induction of altered gene expression profiles in cultured bovine granulosa cells at high cell density

Ingenuity canonical pathways -log(p-value) p-value Ratio z-scorea Number of affected molecules Total number of moleculesb
AMPK Signaling 4.00 0.0001 0.183 −0.471 30 164
Hepatic Fibrosis/Hepatic Stellate Cell Activation 3.76 0.0002 0.180   29 161
Acetate Conversion to Acetyl-CoA 3.55 0.0003 0.800   4 5
Ovarian Cancer Signaling 3.45 0.0004 0.190   23 121
cAMP-mediated signaling 3.25 0.0006 0.162 1.257 32 197
Mitotic Roles of Polo-Like Kinase 3.08 0.0008 0.236   13 55
Glioma Signaling 3.04 0.0009 0.198 0.258 18 91
Cell Cycle Control of Chromosomal Replication 2.87 0.0013 0.308   8 26
Xenobiotic Metabolism Signaling 2.79 0.0016 0.151   33 218
LXR/RXR Activation 2.69 0.0020 0.181 0.775 19 105
Calcium Signaling 2.62 0.0024 0.161 1.698 25 155
Eumelanin Biosynthesis 2.59 0.0026 0.750   3 4
FXR/RXR Activation 2.50 0.0032 0.174   19 109
ATM Signaling 2.50 0.0032 0.214 −1.265 12 56
Ethanol Degradation IV 2.46 0.0035 0.333   6 18
LPS/IL-1 Mediated Inhibition of RXR Function 2.45 0.0035 0.151 0.378 28 185
Glioma Invasiveness Signaling 2.43 0.0037 0.211 0.577 12 57
GADD45 Signaling 2.33 0.0047 0.316   6 19
Superpathway of Cholesterol Biosynthesis 2.31 0.0049 0.280   7 25
Oxidative Ethanol Degradation III 2.26 0.0055 0.357   5 14
  1. az-score reflects activation, if values are positive and inactivation, if values are negative
  2. bTotal number of molecules present on the Bovine Gene 1.0 ST Array that are assigned to specific canonical pathways by IPA