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Table 4 Comparison of microarray data from GC cultured under high vs. normal density conditions in vitro and before and after the pre-ovulatory LH surge in vivo

From: Induction of altered gene expression profiles in cultured bovine granulosa cells at high cell density

Gene symbol Gene title FC in vitro FC in vivo corr. r p-value
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 1.7 75.8 0.997 0.00001
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.9 7.2 0.995 0.00004
WWC2 WW and C2 domain containing 2 1.5 3.9 0.995 0.00004
TACC3 transforming, acidic coiled-coil containing protein 3 −1.7 −5.4 0.995 0.00004
ATAD2 ATPase family, AAA domain containing 2 −1.8 −8.1 0.994 0.00005
INHBA inhibin, beta A −2.4 −29.5 0.994 0.00005
CAPG capping protein (actin filament), gelsolin-like 1.7 7.3 0.994 0.00005
LOC784007 uncharacterized LOC784007; SLAM family member 9-like −2.0 −21.8 0.993 0.00007
ITPKA inositol-trisphosphate 3-kinase A 2.2 6.7 0.993 0.00007
QSOX1 quiescin Q6 sulfhydryl oxidase 1 1.6 5.4 0.992 0.00009
NDRG1 N-myc downstream regulated 1 4.3 63.8 0.992 0.00010
SAT1 spermidine/spermine N1-acetyltransferase 1 1.6 15.0 0.991 0.00013
CDCA3 cell division cycle associated 3 −1.6 −11.0 0.989 0.00017
RGS2 regulator of G-protein signaling 2, 24 kDa 3.3 194.0 0.989 0.00020
HEG1 HEG homolog 1 (zebrafish) −2.1 −29.7 0.985 0.00035
PTX3 pentraxin 3, long 3.0 643.9 0.958 0.00257
SRGN serglycin −4.1 −29.9 0.924 0.00841
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.9 28.5 0.967 0.00166
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 −7.0 −397.6 0.912 0.01140
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.4 14.5 0.898 0.01493
FSHR follicle stimulating hormone receptor −4.6 −4.1 0.896 0.01555
LHCGR luteinizing hormone/choriogonadotropin receptor −2.4 −7.9 0.811 0.05005
AHSG alpha-2-HS-glycoprotein 36.6 152.3 0.809 0.05110
VNN2 vanin 2 5.9 116.0 0.749 0.08659
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 9.6 24.4 0.718 0.10777
  1. FC fold change; corr, correlation, calculated by Pearson Product Moment analysis