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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

Fig. 2

Generation of IL2RG knockout pigs. a An image of IL2RG knockout pigs produced in this study (b) Genotypes of IL2RG knockout female piglets. The dots indicate the deletion mutation in the sequence of IL2RG knockout pigs. c Immunodeficiency presented in IL2RG knockout pigs. The thymic phenotype in IL2RG knockout pigs shows absence of thymus compared to normal thymuses in wild-type pigs. Dotted yellow circle indicates the location of thymus. The histological analysis of the spleens of wild-type and IL2RG knockout pigs indicate that IL2RG knockout pigs lack T and B cells (Original magnification 200×)

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