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Fig. 8 | Reproductive Biology and Endocrinology

Fig. 8

From: Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence

Fig. 8

a Micrographs of immunofluorescent staining of GAD65 in the nucleus raphe magnus (NRM) in different groups of mice. Both GAD65- and Synapsin I-positive neurons were identified, as indicated by white arrows. To see the picture more closely, the area of interested was amplified three times. The original amplification:x400. The scale bar represents 125 μm. b Boxplot showing the number of GAD65+ neurons in the NRM among different treatment groups. The dashed line represents the median value of all mice. Blank: blank control endometrium; Hi-Oza: high-dose Ozagrel group; Lo-Oza: low-dose Ozagrel group; Hi-Dep: platelet depletion with high-dose antibody; Lo-Dep: platelet depletion with low-dose antibody; IgG: non-immune mock antibody. c Scatter plot of hotplate latency vs. the log-transformed number of GAD65-positive neurons in the NRM for all groups of mice; d Scatter plot of plasma corticosterone levels vs. the log-transformed number of GAD65-positive neurons in the NRM for all groups of mice. Each alphabet in the figure represents one experimental observation, and the alphabets are the abbreviations of different treatment groups. C: Blank control; U: Untreated; o: Low-dose Ozagrel; O: High-dose Ozagrel; d: Platelet depletion using low-dose antibody; D: Platelet depletion using high-dose antibody; N: Non-immune IgG. The correlation coefficient and its statistical significance levels are shown in (c) and (d). ***: p < 0.001

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