Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos

Table 2 Characteristics of aneuploid embryos transferred that led to implantation

Patient	n Embryos transferred	Embryos transferred	Outcome
1	1	43, XY, -13, -15, -18	Normal birth, 46, XY
2	1	45, XY, -21	Normal birth, 46, XY
3	2^a	45, XY, -21 46, XX	Normal birth, 46, XY
4	2^b	Partial 47, XX,17p11.2-pter 45, XY, -22	Normal ongoing 46, XX
5	2^c	47, XY, +22 Partial 45, XY,-1plar-p36, 12	Normal ongoing 46, XY
6	1^d	45, XY, -21	Chemical pregnancy

^aThis patient, who had undergone PGS for sex selection (desired sex male), had a 45, XY, -21 and a normal 46, XX female transferred. Since she delivered a healthy male, the pregnancy had to be the result of the 45, XY, -21 embryo
^bTwo embryos were transferred; normal 46, XX per CVS. Pregnancy, therefore, had to arise from partial trisomic embryo transferred. Currently 20 weeks
^cTwo embryos transferred; normal 46, XY per amniocentesis. Embryo leading to pregnancy unknown; Currently 19 weeks
^dChemical pregnancy indicates implantation but not considered a clinical pregnancy; Ploidy unknown

ISSN: 1477-7827